Publications using
In Vivo MicroFlow Kits

(Micronucleus Analysis)

Diet-induced obesity increases the frequency of Pig-a mutant erythrocytes in male C57BL/6J mice

J.K. Wickliffe1, S.D. Dertinger2, D.K. Torous2, S.L. Avlasevich2, B.R. Simon-Friedt1, M.J. Wilson1

1 Tulane University
2 Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 57, Issue 9, December 2016, Pages 668–677
Genotoxicity and subchronic toxicity evaluation of dried Euglena gracilis ATCC PTA-123017

R.R. Simon1, T.D. Vo1, R. Levine2

1 Intertek Scientific and Regulatory Consultancy
2 Algal Scientific Corporation

Regulatory Toxicology and Pharmacology
Volume 80, October 2016, Pages 71–81
Gamma radiation at a human relevant low dose rate is genotoxic in mice

A. Graupner1,2, D.M. Eide1,2, C. Instanes1,2, J.M. Andersen1,2, D.A. Brede2, S.D. Dertinger3, O.C. Lind2, A. Brandt-Kjelsen2, H. Bjerke4, B. Salbu2, D. Oughton2, G. Brunborg1,2, A.K. Olsen1,2

1 Norwegian Institute of Public Health
2 Centre for Environmental Radioactivity (CoE CERAD)
3 Litron Laboratories
4 Norwegian Radiation Protection Authority

Scientific Reports
Volume 6, 06 September 2016, Article 32977
Oral exposure to commercially available coal tar-based pavement sealcoat induces murine genetic damage and mutations

A.S. Long1,2, M. Watson2, V.M. Arlt3, P.A. White1,2

1 University of Ottawa
2 Health Canada
3 King's College London

Environmental and Molecular Mutagenesis
Volume 57, Issue 7, August 2016, Pages 535–545
Cigarette smoke induced genotoxicity and respiratory tract pathology: evidence to support reduced exposure time and animal numbers in tobacco product testing

A. Dalrymple1, P. Ordoñez2, D. Thorne1, D. Walker1, O.M. Camacho1, A. Büttner3, D. Dillon1, C. Meredith1

1 British American Tobacco
2 Vivotecnia Research S.L.
3 Histovia GmbH

Inhalation Toxicology
Volume 28, Issue 7, June 2016, Pages 324-338
Empirical analysis of BMD metrics in genetic toxicology part II: in vivo potency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment

J.W. Wills1, A.S. Long1, G.E. Johnson2, J.C. Bemis3, S.D. Dertinger3, W.Slob4, P.A. White1

1 Health Canada
2 Swansea University Medical School
3 Litron Laboratories
4 National Institute for Public Health and the Environment (RIVM)

Mutagenesis
Volume 31, Issue 3, May 2016, Pages 265-275
Genotoxicity assessment of intravenously injected titanium dioxide nanoparticles in gpt delta transgenic mice

T. Suzuki1, N. Miura1, R. Hojo1, Y. Yanagiba1, M. Suda1, T. Hasegawa2, M. Miyagawa1, 2, R.S. Wang1

1 National Institute of Occupational Safety and Health
2 Mount Fuji Research Institute, Yamanashi Prefectural Government

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 802, May 2016, Pages 30–37
In vivo micronucleus studies with 6 titanium dioxide materials (3 pigment-grade & 3 nanoscale) in orally-exposed rats

E.M. Donner1, A. Myhre1, S.C. Brown2, R. Boatman3, D.B. Warheit2

1 DuPont Haskell
2 Chemours Company
3 Boatman Toxicology Consulting LLC

Regulatory Toxicology and Pharmacology
Volume 74, February 2016, Pages 64–74
In vivo genotoxicity assessment of acrylamide and glycidyl methacrylate

V.N. Dobrovolsky1, M.M. Pacheco-Martinez2, L.P. McDaniel1, M.G. Pearce1, W. Ding1

1 National Center for Toxicological Research, US Food and Drug Administration
2 Universidad Autónoma Metropolitana Iztapalapa

Food and Chemical Toxicology
Volume 87, January 2016, Pages 120–127
Comparison of integrated genotoxicity endpoints in rats after acute and subchronic oral doses of 4-nitroquinoline-1-oxide

D.J. Roberts1,2, M. McKeon3, Y. Xu3, L.F. Stankowski4

1 Bristol-Myers Squibb
2 Rutgers
3 BioReliance Corporation
4 WIL Research

Environmental and Molecular Mutagenesis
Volume 57, Issue 1, January 2016, Pages 17–27
Tissue-specific in vivo genetic toxicity of nine polycyclic aromatic hydrocarbons assessed using the Muta™Mouse transgenic rodent assay

A.S. Long1, 2, C.L. Lemieux2, V.M. Arlt3, P.A. White1,2

1 University of Ottawa
2 Health Canada
3 King's College London

Toxicology and Applied Pharmacology
Volume 290, 1 January 2016, Pages 31–42
Genetic and rat toxicity studies of cyclodextrin glucanotransferase

R.R. Maronpot1, C.A. Hobbs2, J. Davis2, C. Swartz2, M. Boyle2, M. Koyanagi3, S.M. Hayashi3

1 Maronpot Consulting LLC
2 Integrated Laboratory Systems, Inc.
3 San-Ei Gen F.F.I., Inc.

Toxicology Reports
Volume 3, 2016, Pages 381–392
Dietary folic acid protects against genotoxicity in the red blood cells of mice

A.J. MacFarlane1, N.A. Behan1, M.S. Field2, A. Williams1, P.J. Stover2, C.L. Yauk1

1 Health Canada
2 Cornell University

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Volume 779, September 2015, Pages 105–111
Genotoxicity evaluation of the flavonoid, myricitrin, and its aglycone, myricetin

C.A. Hobbs1, C. Swartz1, R. Maronpot2, J. Davis1, L. Recio1, M. Koyanagi3, S.M. Hayashi3

1 Integrated Laboratory Systems, Inc.
2 Maronpot Consulting LLC
3 San-Ei Gen F.F.I.

Food and Chemical Toxicology
Volume 83, September 2015, Pages 283–292
Dose–response assessment of the dermal toxicity of triclosan in B6C3F1 mice

J.L. Fang, M.M. Vanlandingham, B.E. Juliar, G.R. Olson, R.E. Patton, F.A. Beland

National Center for Toxicological Research, Food and Drug Administration

Toxicology Research
Volume 4, 01 July 2015, Pages 867-877
In vivo genotoxicity of estragole in male F344 rats

W. Ding1, D.D. Levy2, M.E. Bishop1, M.G. Pearce1, K.J. Davis2, A.M. Jeffrey3, J.D. Duan3, G.M. Williams3, G.A. White2, L.E. Lyn-Cook1, M.G. Manjanatha1

1 US FDA/National Center for Toxicological Research
2 US FDA/Center for Food Safety and Applied Nutrition
3 New York Medical College

Environmental and Molecular Mutagenesis
Volume 56, Issue 4, May 2015, Pages 356–365
Comparison of male versus female responses in the Pig-a mutation assay

C. Labash1, S.L. Avlasevich1, K. Carlson1, D.K. Torous1, A. Berg1, J.C. Bemis1, J.T. MacGregor2, S.D. Dertinger1

1 Litron Laboratories
2 Toxicology Consulting Services

Mutagenesis
Volume 30, Issue 3, May 2015, Pages 349-357
Rat Pig-a mutation assay responds to the genotoxic carcinogen ethyl carbamate but not the non-genotoxic carcinogen methyl carbamate

J.C. Bemis1, C. Labash1, S.L. Avlasevich1, K. Carlson1, A. Berg1, D.K. Torous1, M. Barragato1, J.T. MacGregor2, S.D. Dertinger1

1 Litron Laboratories
2 Toxicology Consulting Services

Mutagenesis
Volume 30, Issue 3, May 2015, Pages 343-347
Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity

J.E. French1, D.M. Gatti2, D.L. Morgan1, G.E. Kissling3, K.R. Shockley3, G.A. Knudsen4, K.G. Shepard5, H.C. Price6, D. King1, K.L. Witt1, L.C. Pedersen3, S.C. Munger2, K.L. Svenson2, GA. Churchill2

1 Division of the National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH)
2 The Jackson Laboratory
3 National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH)
4 National Cancer Institute (NCI), National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH)
5 Integrated Laboratory Systems Inc.
6 Alion Science and Technology

Environmental Health Perspectives
Volume 123, Issue 3, March 2015, Pages 237-245
Effects of Acute Oral 5-aminotetrazole (5-AT) Exposure to Rats (Rattus norvegicus)

V.H. Adams

Army Public Health Command


12 February 2015
Genotoxicity assessment of melamine in the in vivo Pig-a mutation assay and in a standard battery of assays

H. Tu, M. Zhang, C. Zhou, Z. Wang, P. Huang, H. Ou, Y. Chang

National Shanghai Center for New Drug Safety Evaluation & Research, China State Institute of Pharmaceutical Industry

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 777, 1 January 2015, Pages 62–67
Toxicological assessment of kretek cigarettes: Part 1: background, assessment approach, and summary of findings

E. Roemer, R. Dempsey, M.K. Schorp

Philip Morris International

Regulatory Toxicology and Pharmacology
Volume 70, Supplement 1, 15 December 2014, Pages S2–S14
Assessment of 5-fluorouracil and 4-nitroquinoline-1-oxide in vivo genotoxicity with Pig-a mutation and micronucleus endpoints

C. Zhou1, M. Zhang1, P. Huang1, H. Tu1, Z. Wang1, S.D. Dertinger2, D.K. Torous2, Y. Chang1

1 National Shanghai Center for New Drug Safety Evaluation and Research, China State Institute of Pharmaceutical Industry
2 Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 55, Issue 9, December 2014, Pages 735–740
Quantifying murine bone marrow and blood radiation dose response following 18F-FDG PET with DNA damage biomarkers

G. Manning1, K. Taylor2, P. Finnon1, J.A. Lemon2, D.R. Boreham2, C. Badie1

1 Public Health England
2 McMaster University

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Volume 770, December 2014, Pages 29–36
Time course of lung retention and toxicity of inhaled particles: short-term exposure to nano-Ceria

J. Keller1, W. Wohlleben1, L. Ma-Hock1, V. Strauss1, S. Gröters1, K. Küttler1, K. Wiench1, C. Herden2, G. Oberdörster3, B. van Ravenzwaay1, R. Landsiedel1

1 BASF SE
2 Justus-Liebig-University
3 University of Rochester

Archives of Toxicology
Volume 88, Issue 11, November 2014, Pages 2033–2059
Sex-specific dose-response analysis of genotoxicity in cyproterone acetate-treated F344 rats

W. Ding, M.E. Bishop, M.G. Pearce, K.J. Davis, G.A. White, 1, L.E. Lyn-Cook, M.G. Manjanatha

US FDA/National Center for Toxicological Research

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 774, 1 November 2014, Pages 1–7
Stability in candy products of neocandenatone, a non-genotoxic purple pigment from Dalbergia congestiflora heartwood

C.G. Gutiérrez-Zúñiga1, M. Arriaga-Alba2, C. Ordaz-Pichardo1, P. Gutiérrez-Macías1, B.E. Barragán-Huerta1

1 Instituto Politécnico Nacional
2 Hospital Juárez de México

Food Research International
Volume 65, Part B, November 2014, Pages 263–271
Inter-laboratory validation of the in-vivo flow cytometric micronucleus analysis method (MicroFlow®) in China

Y. Chang1, C. Zhou1, F. Huang2, D.K. Torous3, Y. Luan4, C. Shi5, H. Wang6, X. Wang7, N. Wei8, Z. Xia9, Z. Zhong10, M. Zhang1, F. An6, Y. Cao4, X. Geng7, Y. Jiang10, Q. Ju8, Y. Yu5, Ji. Zhu9, S.D. Dertinger3, B. Li7, M. Liao5, B. Yuan9, T. Zhang9, J. Yu11, Z. Zhang11, Q. Wang2, J. Ma1

1 National Shanghai Center for New Drug Safety Evaluation & Research, China State Institute of Pharmaceutical Industry
2 Center for Drug Evaluation, China Food and Drug Administration
3 Litron Laboratories
4 Center for Drug Safety Evaluation and Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
5 Beijing Institute of Pharmacology and Toxicology, National Beijing Center for Drug Safety Evaluation and Research
6 Joinn Laboratories
7 Institute for Food and Drug Safety Evaluation, National Institute for Food and Drug Control
8 National Chengdu Center for Safety Evaluation of Drugs
9 Center for Evaluation of Drug Safety, Second Military Medical University
10 WuXi AppTec (Suzhou) Co., Ltd.
11 Becton Dickinson Medical Devices (Shanghai) Co Ltd.

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 772, 15 September 2014, Pages 6–13
Persistence of cisplatin-induced mutagenicity in hematopoietic stem cells: implications for secondary cancer risk following chemotherapy

S.D. Dertinger1, S.L. Avlasevich1, D.K. Torous1, J.C. Bemis1, S. Phonethepswath1, C. Labash1, K. Carlson1, J. Mereness1, J. Cottom1, J. Palis2, J.T. MacGregor3

1 Litron Laboratories
2 University of Rochester Medical Center
3 Toxicology Consulting Services

Toxicological Sciences
Volume 140, Issue 2, 01 August 2014, Pages 307-314
Concurrent evaluation of general, immune, and genetic toxicity endpoints as part of an integrated testing strategy

M.R. Schisler, R. Sura, N.R. Visconti, L.K. Sosinski, L.A. Murphy, M.J. LeBaron, D.R. Boverhof

The Dow Chemical Company

Environmental and Molecular Mutagenesis
Volume 55, Issue 7, August 2014, Pages 530–541
Evaluation of the Pig-a, micronucleus, and comet assay endpoints in a 28-day study with ethyl methanesulfonate

W.C. Gunther1, S.L. Coffing1, D.A. Dickinson1, M.E. Engel1, R.D. Fiedler2, S.D. O'Lone1, K.E. Sanok1, C.J. Thiffeault2, T.J. Shutsky1, M.J. Schuler1, K.L. Dobo1

1 Pfizer Global Research and Development
2 Covance Genetic Toxicology

Environmental and Molecular Mutagenesis
Volume 55, Issue 6, July 2014, Pages 492–499
The influence of Trp53 in the dose response of radiation-induced apoptosis, DNA repair and genomic stability in murine haematopoietic cells

J.A. Lemon, K. Taylor, K. Verdecchia, N. Phan, D.R. Boreham

McMaster University

Dose Response
Volume 12, Issue 3, July 2014, Pages 365-385
Radiation-induced DNA damage and the relative biological effectiveness of 18F-FDG in wild-type mice

K. Taylor, J.A. Lemon, D.R. Boreham

McMaster University

Mutagenesis
Volume 29, Issue 4, July 2014, Pages 279-287
Diethylnitrosamine genotoxicity evaluated in sprague dawley rats using pig-a mutation and reticulocyte micronucleus assays

S.L. Avlasevich1, S. Phonethepswath1, C. Labash1, K. Carlson1, D.K. Torous1, J. Cottom1, J.C. Bemis1, J.T. MacGregor2, S.D. Dertinger1

1 Litron Laboratories
2 Toxicology Consulting Services

Environmental and Molecular Mutagenesis
Volume 55, Issue 5, June 2014, Pages 400–406
Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone

S.D. Dertinger1, S. Phonethepswath1, S.L. Avlasevich1, D.K. Torous1, J. Mereness1, J. Cottom1, J.C. Bemis1, J.T. MacGregor2

1 Litron Laboratories
2 Toxicology Consulting Services

Environmental and Molecular Mutagenesis
Volume 55, Issue 4, May 2014, Pages 299–308
Flow cytometric analysis of micronuclei in rat peripheral blood: An interlaboratory reproducibility study

S. Kasamoto1, D. Mukai1, S. Masumori1, K. Suzuki1, R. Tanaka1, D.K. Torous2, J. Yamate3, M. Hayashi1

1 BioSafety Research Center (BSRC)
2 Litron Laboratories
3 Osaka Prefecture University

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 762, 1 March 2014, Pages 39–42
Genotoxicity of doxorubicin in F344 rats by combining the comet assay, flow-cytometric peripheral blood micronucleus test, and pathway-focused gene expression profiling

M.G. Manjanatha1, M.E. Bishop1, M.G. Pearce1, R. Kulkarni2, L.E. Lyn-Cook1, W. Ding1

1 US Food and Drug Administration, National Center for Toxicological Research
2 BioReliance Corporation

Environmental and Molecular Mutagenesis
Volume 55, Issue 1, January 2014, Pages 24–34
Comparison of three-colour flow cytometry and slide-based microscopy for the scoring of micronucleated reticulocytes in rat bone-marrow and peripheral blood

C. Zhou1, Q. Wang2, Z. Wang1, Y. Chang1

1 National Shanghai Center for New Drug Safety Evaluation & Research, China State Institute of Pharmaceutical Industry
2 Center for Drug Evaluation, State Food and Drug Administration

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 758, Issues 1–2, 12 December 2013, Pages 12–17
Assessment of the genotoxic potential of azidothymidine in the comet, micronucleus, and pig-a assay

M. Guérard1, J. Koenig1, M. Festag1, S.D. Dertinger2, T. Singer1, G. Schmitt1, and A. Zeller1

1 F. Hoffmann-La Roche AG
2 Litron Laboratories

Toxicological Sciences
Volume 135, Issue 2, October 2013, Pages 309-316
Subchronic exposure to ethyl tertiary butyl ether resulting in genetic damage in Aldh2 knockout mice

Z. Weng1, M. Suda1, K. Ohtani1, N. Mei2, T. Kawamoto3, T. Nakajima4, R.S. Wang1

1 Japan National Institute of Occupational Safety and Health
2 National Center for Toxicological Research
3 University of Occupational and Environmental Health
4 College of Life and Health Sciences, Chubu University

Toxicology
Volume 311, Issue 3, 15 September 2013, Pages 107–114
Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens

J.A. Bhalli, J.G. Shaddock, M.G. Pearce, V.N. Dobrovolsky

National Center for Toxicological Research, US Food and Drug Administration

Mutagenesis
Volume 28, Issue 4, July 2013, Pages 447-455
Evaluating the weak in vivo micronucleus response of a genotoxic carcinogen, Aristolochic acids

J.A. Bhalli, W. Ding, J.G. Shaddock, M.G. Pearce, V.N. Dobrovolsky, R.H. Heflich

National Center for Toxicological Research, U.S. Food and Drug Administration

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 753, Issue 2, 15 May 2013, Pages 82–92
Pharmacological inhibition of Polo Like Kinase 2 (PLK2) does not cause chromosomal damage or result in the formation of micronuclei

K. Fitzgerald, M. Bergeron, C. Willits, S. Bowers, D.L. Aubele, E. Goldbach, G. Tonn, D. Ness, A. Olaharski

Elan Pharmaceuticals Inc.

Toxicology and Applied Pharmacology
Volume 269, Issue 1, 15 May 2013, Pages 1–7
Flow cytometric analysis of Pig-a gene mutation and chromosomal damage induced by procarbazine hydrochloride in CD-1 mice

S. Phonethepswath1, S.L. Avlasevich1, D.K. Torous1, J. Mereness1, J.C. Bemis1, J.T. MacGregor2, S.D. Dertinger1

1 Litron Laboratories
2 Toxicology Consulting Services

Environmental and Molecular Mutagenesis
Volume 54, Issue 4, May 2013, Pages 294–298
Influence of counting methodology on erythrocyte ratios in the mouse micronucleus test

M.J. LeBaron1, M.R. Schisler1, D.K. Torous2, S.D. Dertinger2, B.B. Gollapudi1

1 The Dow Chemical Company
2 Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 54, Issue 3, April 2013, Pages 222–228
The automated micronucleus assay for early assessment of genotoxicity in drug discovery

K. Tilmant1,2, H.H.J. Gerets1, P. De Ron1, C. Cossu-Leguille2, P. Vasseur2, S. Dhalluin1, F.A. Atienzar1

1 UCB Pharma
2 CNRS Université Paul Verlaine

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 751, Issue 1, 18 February 2013, Pages 1 – 11
No evidence for transgenerational genomic instability in the F1 or F2 descendants of Muta™Mouse males exposed to N-ethyl-N-nitrosourea

J.M. O’Brien, A. Williams, J. Gingerich, G.R. Douglas, F. Marchetti, C.L. Yauk

Health Canada

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Volumes 741–742, January–February 2013, Pages 11–17
Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds

S.D. Dertinger1, S. Phonethepswath1, S.L. Avlasevich1, D.K. Torous1, J. Mereness1, S.M. Bryce1, J.C. Bemis1, S. Bell1, P. Weller1 and J.T. MacGregor2

1 Litron Laboratories
2 Toxicology Consulting Services

Toxicological Sciences
Volume 130, Issue 2, December 2012, Pages 328-348
Genetic differences in transcript responses to low-dose ionizing radiation identify tissue functions associated with breast cancer susceptibility

A.M. Snijders, F. Marchetti, S. Bhatnagar, N. Duru, J. Han, Z. Hu, J.H. Mao, J.W. Gray, A.J. Wyrobek

Lawrence Berkeley National Laboratory

PLOS ONE
Volume 7, Issue 10, October 2012, Article e45394
Part 2. Assessment of genotoxicity after exposure to diesel exhaust from U.S. 2007-compliant diesel engines: report on 1- and 3-month exposures in the ACES bioassay

J.C. Bemis,D.K. Torous, S.D. Dertinger

Litron Laboratories

Research Reports Health Effects Institute
Research Report 166, September 2012, Pages 125-157
In vivo flow cytometric Pig-a and micronucleus assays: highly sensitive discrimination of the  carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated -dose designs

D.K. Torous1, S.Phonethepswath1, S.L. Avlasevich1, J. Mereness1, S.M. Bryce1, J.C. Bemis1, P. Weller1, S. Bell1, C. Gleason2, L.L. Custer2, J.T. MacGregor3, S.D. Dertinger1

1 Litron Laboratories
2 Bristol-Myers Squibb
3 Toxicology Consulting Services

Environmental and Molecular Mutagenesis
Volume 53, Issue 6, July 2012, Pages 420 – 428
Genotoxicity of styrene-7,8-oxide and styrene in Fisher 344 rats: A 4-week inhalation study

L. Gaté, , J.C. Micillino, S. Sébillaud, C. Langlais, F. Cosnier, H. Nunge, C. Darne, Y. Guichard, S.Binet

Institut National de Recherche et Sécurité

Toxicology Letters
Volume 211, Issue 3, 20 June 2012, Pages 211 – 219
Silica nanoparticles administered at the maximum tolerated dose induce genotoxic effects through an inflammatory reaction while gold nanoparticles do not

T.R. Downs1, M.E. Crosby1, T. Hu1, S. Kumar2, A. Sullivan1, K. Sarlo1, B.Reeder1, M. Lynch1, M. Wagner1, T. Mills1, S. Pfuhler1

1 The Procter and Gamble Co.
2 BioReliance Corp.

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 745, Issues 1 – 2, 14 June 2012, Pages 38 – 50
In vivo genotoxicity of furan in F344 rats at cancer bioassay doses

W. Ding, D.M. Petibone, J.R. Latendresse, M.G. Pearce, L. Muskhelishvili, G.A. White, C.W. Chang, R.A. Mittelstaedt, J.G. Shaddock, L.P. McDaniel, D.R. Doerge, S.M. Morris, M.E. Bishop, M.G. Manjanatha, A. Aidoo, R.H. Heflich

US FDA/National Center for Toxicological Research

Toxicology and Applied Pharmacology
Volume 261, Issue 2, 1 June 2012, Pages 164 – 171
Supplemental dietary folic acid has no effect on chromosome damage in erythrocyte progenitor cells of mice

B.G. Swayne1, N.A. Behan1, A. Williams1, P.J. Stover2, C.L. Yauk1, A.J. MacFarlane1

1 Health Canada
2 Cornell University

Journal of Nutrition
Volume 142, Issue 5, 01 May 2012, Pages 813-817
Genotoxicity of styrene-acrylonitrile trimer in brain, liver, and blood cells of weanling F344 rats

C.A. Hobbs1, R.S. Chhabra2, L. Recio1, M. Streickler1, K.L. Witt2

1 ILS, Inc.
2 Division of the National Toxicology Program, National Institute of Environmental Health Sciences

Environmental and Molecular Mutagenesis
Volume 53, Issue 3, April 2012, Pages 227 – 238
Evaluation of the genotoxicity of the food additive, gum ghatti

C.A. Hobbs1, C. Swartz1, R. Maronpot2, J. Davis2, L. Recio1, S.M. Hayashi3

1 ILS, Inc.
2 Maronpot Consulting LLC
3 San-Ei Gen F.F.I., Inc.

Food and Chemical Toxicology
Volume 50, Issues 3–4, March–April 2012, Pages 854–860
Genotoxicity of furan in Big Blue rats

L.P. McDaniel, W. Ding, V.N. Dobrovolsky, J.G. Shaddock Jr, R.A. Mittelstaedt, D.R. Doerge, R.H. Heflich

U.S. Food and Drug Administration/National Center for Toxicological Research

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 742, Issues 1 – 2, 18 February 2012, Pages 72 – 78
Assessment of the in vivo genotoxicity of isomers of dinitrotoluene using the alkaline Comet and peripheral blood micronucleus assays

E.M. Lent, L.C.B. Crouse, M.J. Quinn Jr, S.M. Wallace

US Army Public Health Command

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 742, Issues 1–2, 18 February 2012, Pages 54–60
Biological effects and adaptive response from single and repeated computed tomography scans in reticulocytes and bone marrow of C57BL/6 mice

N. Phan, M. De Lisio, G. Parise ,D.R. Boreham

McMaster University

Radiation Research
Volume 177, Issue 2, February 2012, Pages 164-175
Interlaboratory Pig-a gene mutation assay trial: Studies of 1,3-propane sultone with immunomagnetic enrichment of mutant erythrocytes

S.D. Dertinger1, S. Phonethepswath1, P. Weller1, S. Avlasevich1, D.K. Torous1, J.A. Mereness1, S.M. Bryce1, J.C. Bemis1, S. Bell1, S. Portugal2, M. Aylott3, J.T. MacGregor4

1 Litron Laboratories
2 Pfizer Global R&D
3 GlaxoSmithKline
4 Toxicology Consulting Services

Environmental and Molecular Mutagenesis
Volume 52, Issue 9, December 2011, Pages 748–755
Integration of Pig-a, micronucleus, chromosome aberration, and Comet assay endpoints in a 28-day rodent toxicity study with 4-nitroquinoline-1-oxide

L.F. Stankowski Jr, D.J. Roberts, H. Chen, T. Lawlor, M. McKeon, H. Murli, A. Thakur, Y. Xu

Covance Laboratories

Environmental and Molecular Mutagenesis
Volume 52, Issue 9, December 2011, Pages 738–747
Report on stage III Pig-a mutation assays using benzo[a]pyrene

J.A. Bhalli1, J.G. Shaddock1, M.G. Pearce1, V.N. Dobrovolsky1, X. Cao1, R.H. Heflich1, H.W. Vohr2

1 National Center for Toxicological Research, U.S. Food and Drug Administration
2 Bayer HealthCare AG

Environmental and Molecular Mutagenesis
Volume 52, Issue 9, December 2011, Pages 731–737
Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea-comparison with other in vivo genotoxicity endpoints

Z. Cammerer1, J.A. Bhalli2, X. Cao2, S.L. Coffing1, D. Dickinson1, K.L. Dobo1, V.N. Dobrovolsky2, M. Engel1, R.D. Fiedler1, W.C. Gunther1, R.H. Heflich2, M.G. Pearce2, J.G. Shaddock2, T. Shutsky1, C.J. Thiffeault1, M. Schuler1

1 Pfizer Global Research and Development
2 U.S. Food and Drug Administration/National Center for Toxicological Research

Environmental and Molecular Mutagenesis
Volume 52, Issue 9, December 2011, Pages 721–730
Assessment of genotoxicity induced by 7,12-dimethylbenz(a)anthracene or diethylnitrosamine in the Pig-a, micronucleus and Comet assays integrated into 28-day repeat dose studies

J. Shi, L. Krsmanovic, S. Bruce, T. Kelly, M. Paranjpe, K. Szabo, M. Arevalo, S. Atta-Safoh, F. Debelie, M.K. LaForce, J. Sly, S. Springer

BioReliance Corporation

Environmental and Molecular Mutagenesis
Volume 52, Issue 9, December 2011, Pages 711–720
International Pig-a gene mutation assay trial (stage III): results with N-methyl-N-nitrosourea

A.M. Lynch1, A. Giddings1, L. Custer2, C. Gleason2, A. Henwood2, M. Aylott1, J. Kenny1

1 GlaxoSmithKline
2 Bristol-Myers Squibb

Environmental and Molecular Mutagenesis
Volume 52, Issue 9, December 2011, Pages 699–710
Trimethoprim-sulfamethoxazole increase micronuclei formation in peripheral blood from weanling well-nourished and malnourished rats

R. Ortiz, H. Medina, E. Cortés, E. Cervantes, L. Rodríguez

Universidad Autónoma Metropolitana-Iztapalapa

Environmental and Molecular Mutagenesis
Volume 52, Issue 8, October 2011, Pages 673–680
Sidestream tobacco smoke is a male germ cell mutagen

F. Marchetti1, A. Rowan-Carroll2, A. Williams2, A. Polyzos1, M.L. Berndt-Weis2, C.L. Yauk2

a Lawrence Berkeley National Laboratory
b Health Canada

Proceedings of the National Academy of Sciences
Volume 108, Issue 31, 02 Aug 2011, Pages 12811-12814
Evaluation of a mult-endpoint assay in rats, combining the bone-marrow micronucleus test, the Comet assay and the flow-cytometric peripheral blood micronucleus test

D.E. Bowen1, J.H. Whitwell2, L. Lillford2, D. Henderson2, D. Kidd2, S. Mc Garry2, G. Pearce2, C. Beevers2, D.J. Kirkland3

1 JSC International Ltd.
2 Covance Laboratories Ltd.
3 Kirkland Consulting

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 722, Issue 1, 18 May 2011, Pages 7–19
The rat gut micronucleus assay: a good choice for alternative in vivo genetic toxicology testing strategies

Stephanie Coffing, Maria Engel, Donna Dickinson, Catherine Thiffeault, Richard Spellman, Thomas Shutsky, Maik Schuler,

Pfizer Global Research and Development

Environmental and Molecular Mutagenesis
Volume 52, Issue 4, May 2011, Pages 269–279
Toxicologic characterization of a novel explosive, triaminoguanidinium-1-methyl-5-nitriminotetrazolate (TAG-MNT), in female rats and in vitro assay

L.R. Williams, C.J. Cao, E.M. Lent, L.C.B. Crouse, M.A. Bazar, M.S. Johnson

US Army Public Health Command (Provisional)

Journal of Toxicology and Environmental Health Sciences
Volume 3, Issue 3, March 2011, Pages 80-84
Exercise-induced protection of bone marrow cells following exposure to radiation

M. De Lisio, N. Phan, D.R. Boreham, G. Parise

McMaster University

Applied Physiology, Nutrition, and Metabolism
Volume 36, Issue 1, February 2011, Pages 80-87
Genotoxicity assessment of an energetic propellant compound, 3-nitro-1,2,4-triazol-5-one (NTO)

G. Reddy1, J. Song2, P. Kirby2, E.M. Lent1, L.C.B. Crouse1, M.S. Johnson1

1 U.S. Army Public Health Command
2 SITEK Research Laboratories

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 719, Issues 1–2, 3 February 2011, Pages 35–40
Evaluation of a modified CD71 MicroFlow® method for the flow cytometric analysis of micronuclei in rat bone marrow erythrocyte

R.D. Fiedler1, S.K. Weiner2, M. Schuler1

1 Pfizer Global Research and Development
2 Johnson & Johnson Pharmaceutical Research and Development

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 703, Issue 2, 21 December 2010, Pages 122–129
Rationale of genotoxicity testing of nanomaterials: regulatory requirements and appropriateness of available OECD test guidelines

David B. Warheit, E. Maria Donner

DuPont Haskell Global Centers for Health & Environmental Sciences

Nanotoxicology
Volume 4, Issue 4, December 2010, Pages 409-413
Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies

A. Rothfuss1, M. O’Donovan2, M. De Boeck3, D. Brault4, A. Czich4, L. Custer5, S. Hamada6, U. Plappert-Helbig7, M. Hayashi10, J. Howe8, A.R. Kraynak9, B.J. van der Leede3, M. Nakajima10, C. Priestley2, V. Thybaud4, K. Saigo11, S. Sawant12, J. Shi13, R. Storer9, M. Struwe14, E. Vock15, S. Galloway9

1 Bayer Schering Pharma AG
2 AstraZeneca R&D
3 Johnson & Johnson Pharmaceutical Research & Development (J&JPRD)
4 Sanofi Aventis
5 Bristol-Myers Squibb
6 Mitsubishi Chemical Medience Corporation
7 Novartis Institutes for Biomedical Research
8 GlaxoSmithKline R&D
9 Merck Research Laboratories
10 Biosafety Research Center, Foods, Drugs and Pesticides
11 Shin Nippon Biomedical Laboratories
12 Amgen Inc.
13 BioReliance
14 F.Hoffmann-La Roche Ltd.
15 Boehringer Ingelheim Pharma GmbH & Co. KG

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 702, Issue 1, 30 September 2010, Pages 40–69
Increased DNA damage in hematopoietic cells of mice with graft-versus-host disease

Y. Kusunoki1, K. Hamasaki1, K. Koyama1, K. Imai1, T. Hayashi1, P.J. Martin1,2, K. Nakachi1

1 Radiation Effects Research Foundation
2 Fred Hutchinson Cancer Research Center

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Volume 689, Issues 1–2, 7 July 2010, Pages 59–64
Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies

S.D. Dertinger1, S. Phonethepswath1, D. Franklin1, P. Weller1, D.K. Torous1, S.M. Bryce1, S. Avlasevich1, J.C. Bemis1, O. Hyrien2, J. Palis2, J.T. MacGregor3

1 Litron Laboratories
2 University of Rochester Medical Center
3 Toxicology Consulting Services

Toxicological Sciences
Volume 115, Issue 2, June 2010, Pages 401-411
The genotoxicity of acrylamide and glycidamide in Big Blue rats

N. Mei, L.P. McDaniel, V.N. Dobrovolsky, X. Guo, J.G. Shaddock, R.A. Mittelstaedt, M. Azuma, S.D. Shelton, L.J. McGarrity, D.R. Doerge, R.H. Heflich

National Center for Toxicological Research, Food and Drug Administration

Toxicological Sciences
Volume 115, Issue 2, June 2010, Pages 412-421
Flow cytometry peripheral blood micronucleus test in vivo: determination of potential thresholds for aneuploidy induced by spindle poisons

Z. Cammerer1,2, M.M. Schumacher3, M. Kirsch-Volders2, W. Suter1, A. Elhajouji1

1 Novartis Institutes for BioMedical Research
2 Vrije Universiteit Brussel
3 Novartis Pharma AG

Environmental and Molecular Mutagenesis
Volume 51, Issue 4, May 2010, Pages 278–284
Integration of in vivo genotoxicity and short-term carcinogenicity assays using F344 gpt delta transgenic rats: in vivo mutagenicity of 2,4-diaminotoluene and 2,6-diaminotoluene structural isomers

N. Toyoda-Hokaiwado1, T. Inoue1, K. Masumura1, H. Hayashi2, Y. Kawamura2, Y. Kurata2, M. Takamune1, M. Yamada1, H. Sanada3, T. Umemura1, A.Nishikawa1, T. Nohmi1

1 National Institute of Health Sciences
2 Meiji Seika Kaisha, Ltd
3 Kaken Pharmaceutical Co.

Toxicological Sciences
Volume 114, Issue 1, March 2010, Pages 71-78
Validating high-throughput micronucleus analysis of peripheral reticulocytes for radiation biodosimetry: benchmark against dicentric and CBMN assays in a mouse model

Y. Chen1, Y. Tsai1, I. Nowak1, N. Wang1, O. Hyrien1, R. Wilkins2, C. Ferrarotto2, H. Sun1, S.D. Dertinger3

1 University of Rochester Medical Center
2 Health Canada
3 Litron Laboratories

Health Physics
Volume 98, Issue 2, February 2010, Pages 218-227
No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days

Kristine L. Witt1, David E. Malarkey1, Cheryl A. Hobbs2, Jeffrey P. Davis2, Grace E. Kissling1, William Caspary1, Gregory Travlos1, Leslie Recio2

1 NIEHS/NTP, National Institutes of Health
2 ILS, Inc.

Environmental and Molecular Mutagenesis
Volume 51, Issue 1, January 2010, Pages 80–88
Gamma-radiation induces micronucleated reticulocytes in 3D bone marrow bioreactors in vitro

H. Sun1,3, S.D. Dertinger2, O. Hyrien2, J.H.D. Wu3, Y. Chen1

1 University of Rochester Medical Center
2 Litron Laboratories
3 University of Rochester

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 680, Issues 1–2, November–December 2009, Pages 49–55
Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation

J.P. Goff1, D.S. Shields1, M. Seki1, S. Choi1, M.W. Epperly1, T. Dixon1, H. Wang1, C.J. Bakkenist1, S.D. Dertinger2, D.K. Torous2, J. Wittschieben1, R.D. Wood1, J.S. Greenberger1

1 University of Pittsburgh School of Medicine
2 Litron Laboratories

Radiation Research
Volume 172, Issue 2, August 2009, Pages 165-174
Inhalation of formaldehyde does not induce systemic genotoxic effects in rats

G. Speit1, J. Zeller1, O. Schmid1, A. Elhajouji2, L. Ma-Hock3, S. Neuss1

1 Universität Ulm
2 Novartis Pharma AG
3 BASF SE

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 677, Issues 1–2, June–July 2009, Pages 76–85
Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: effect of age

S.D. Dertinger1, J.C. Bemis1, S. Phonethepswath1, Y. Tsai2, I. Nowak2, O. Hyrien2, J. Palis2, Y. Chen2

1 Litron Laboratories
2 University of Rochester Medical Center

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 675, Issues 1–2, 30 April 2009, Pages 77–80
Saw palmetto extract induces nuclear heterogeneity in mice

W. Trinachartvanit1, B.M. Francis2, A.L. Rayburn2

1 Mahidol University
2 University of Illinois

Environmental Toxicology and Pharmacology
Volume 27, Issue 1, January 2009, Pages 149–154
Pharmacokinetics, dose-range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice

M.G. Manjanatha1, S.D. Shelton1, V.N. Dobrovolsky1, J.G. Shaddock1, L.G. McGarrity1, D.R. Doerge1, N.W. Twaddle1, C.J. Lin1, J.J. Chen1, D.R. Mattison2, S.M. Morris1

1 National Center for Toxicological Research (NCTR), Food and Drug Administration (FDA)
2 NIH, NICHD

Environmental and Molecular Mutagenesis
Volume 49, Issue 8, October 2008, Pages 585–593
Evaluation of the micronucleus assay in bone marrow and peripheral blood of rats for the determination of cigarette mainstream-smoke activity

E. Van Miert, P. Vanscheeuwijck, K. Meurrens, W. Gomm, P.M. Terpstra

Philip Morris Research Laboratories bvba

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 652, Issue 2, 30 April 2008, Pages 131–138
Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals

K.L. Witt1, E. Livanos2, G.E. Kissling1, D.K. Torous3, W. Caspary1, R.R. Tice2, L. Recio2
 

1 National Institute of Environmental Health Sciences, National Institutes of Health
2 Integrated Laboratory Systems, Inc.
3 Litron Laboratories

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 649, Issues 1–2, 8 January 2008, Pages 101–113
p27kip1 deficiency impairs G2/M arrest in response to DNA damage, leading to an increase in genetic instability

S.R. Payne1, S. Zhang2, K. Tsuchiya1, R. Moser1, K.E. Gurley1, G. Longton1, J. deBoer2, C.J. Kemp1

1 Fred Hutchinson Cancer Research Center
2 University of Victoria

Molecular and Cellular Biology
Volume 28, Issue 1, January 2008, Pages 258-268
Radiation sensitivity and genomic instability in the hematopoietic system: Frequencies of micronucleated reticulocytes in whole-body X-irradiated BALB/c and C57BL/6 mice

K. Hamasaki, K. Imai, T. Hayashi, K. Nakachi, Y. Kusunoki

Radiation Effects Research Foundation

Cancer Science
Volume 98, Issue 12, December 2007, Pages 1840–1844
Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry

S.D. Dertinger1, Y. Tsai2, I. Nowak2, O. Hyrien2, H. Sun2, J.C. Bemis1, D.K. Torous1, P. Keng2, J. Palis2, Y. Chen2

1 Litron Laboratories
2 University of Rochester Medical Center

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 634, Issues 1–2, 1 December 2007, Pages 119–125
Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53-haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC

V.N. Dobrovolsky1, J.G. Shaddock1, R.A. Mittelstaedt1, M.E. Bishop1, S.M. Lewis1, F.W. Lee1, A. Aidoo1, J.E.A. Leakey1, J.K. Dunnick2, R.H. Heflich1

1 US Food and Drug Administration, National Center for Toxicological Research
2 National Institute of Environmental Health Sciences, National Institutes of Health

Environmental and Molecular Mutagenesis
Volume 48, Issue 3-4, April - May 2007, Pages 270–282
Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine

L.S. Von Tungeln, L.D. Williams, D.R. Doerge, J.G. Shaddock, L.J. McGarrity, S.M. Morris, R.A. Mittelstaedt, R.H. Heflich, F.A. Beland

National Center for Toxicological Research, Food and Drug Administration

Environmental and Molecular Mutagenesis
Volume 48, Issue 3-4, April - May 2007, Pages 258–269
Comparison of the peripheral blood micronucleus test using flow cytometry in rat and mouse exposed to aneugens after single-dose applications

Z. Cammerer1, A. Elhajouji1, M. Kirsch-Volders2, W. Suter1

1 Novartis Pharma AG
2 Vrije Universiteit Brussel

Mutagenesis
Volume 22, Issue 2, March 2007, Pages 129-134
In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test

M. Hayashi1, J.T. MacGregor2, D.G. Gatehouse3, D.H. Blakey4, S.D. Dertinger5, L. Abramsson-Zetterberg6, G. Krishna7, T. Morita8, A. Russo9, N. Asano10, H. Suzuki11, W. Ohyama12, D. Gibson13

1 National Institute of Health Sciences
2 Toxicology Consulting Services
3 Covance Laboratories Ltd
4 Health Canada
5 Litron Laboratories
6 National Food Administration
7 MGI Pharma
8 Division of Safety Information on Drug, Food and Chemicals, National Institute of Health Sciences
9 University of Padova
10 Nitto Denko Corporation
11 Ina Research Inc.
12 Yakult Central Institute for Microbiological Research
13 The Procter & Gamble Company

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 627, Issue 1, 3 February 2007, Pages 10–30
In vivo micronucleus test with flow cytometry after acute and chronic exposures of rats to chemicals

Z. Cammerer, A. Elhajouji, W. Suter

Novartis Pharma AG

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 626, Issues 1–2, 10 January 2007, Pages 26–33
Fractionated exposure of high energy iron ions has a sparing effect in vivo

P.Y. Chang, J. Bakke, A. Puey

SRI International

Advances in Space Research
Volume 40, Issue 4, 2007, Pages 568–575
Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: II. An efficient method of monitoring chromosomal damage in the rat

J.T. MacGregor1, M.E. Bishop1, J.P. McNamee2, M. Hayashi3, N. Asano4, A. Wakata5, M. Nakajima6, J. Saito5, A. Aidoo1, M.M. Moore1, S.D. Dertinger7

1 FDA National Center for Toxicological Research,
2 Health Canada
3 National Institute of Health Sciences
4 Nitto Denko Corporation
5 Astellas Pharma, Inc.
6 An-Pyo Center
7 Litron Laboratories

Toxicological Sciences
Volume 94, Issue 1, November 2006, Pages 92-107
Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: I. Intra- and interlaboratory comparison with microscopic scoring

S.D. Dertinger1, M.E. Bishop2, J.P. McNamee3, M. Hayashi4, T. Suzuki4, N. Asano5, M. Nakajima6, J. Saito7, M. Moore2, D.K. Torous1, J.T. MacGregor2

1 Litron Laboratories
2 U.S. Food and Drug Administration, National Center for Toxicological Research
3 Health Canada
4 National Institute of Health Sciences
5 Nitto Denko Corporation
6 An-Pyo Center
7 Astellas Pharma Inc.

Toxicological Sciences
Volume 94, Issue 1, November 2006, Pages 83-91
Health effects of subchronic exposure to environmental levels of hardwood smoke

M.D. Reed1, M.J. Campen1, A.P. Gigliotti1, K.S. Harrod1, J.D. McDonald1, J.C. Seagrave1, J.L. Mauderly1, S.K. Seilkop2

1 Lovelace Respiratory Research Institute
2 SKS Consulting Services

Inhalation Toxicology
Volume 18, Issue 8, July 2006, Pages 523-539
Practical threshold for micronucleated reticulocyte induction observed for low doses of mitomycin C, Ara-C and colchicine

N. Asano1, D.K. Torous2, C.R. Tometsko2, S.D. Dertinger2, T. Morita3, M. Hayashi3

1 Nitto Denko Corporation
2 Litron Laboratories
3 National Institute of Health Sciences

Mutagenesis
Volume 21, Issue 1, January 2006, Pages 15-20
Performance of flow cytometric analysis for the micronucleus assay--a reconstruction model using serial dilutions of malaria-infected cells with normal mouse peripheral blood

D. Torous1, N. Asano2, C. Tometsko1, S. Sugunan1, S. Dertinger1, T. Morita3, M. Hayashi3

1 Litron Laboratories
2 Nitto Denko Corporation
3 National Institute of Health Sciences

Mutagenesis
Volume 21, Issue 1, January 2006, Pages 11-13
Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice

M.G. Manjanatha, A. Aidoo, S.D. Shelton, M.E. Bishop, L.P. McDaniel, L.E. Lyn-Cook, D.R. Doerge

US FDA/National Center for Toxicological Research

Environmental and Molecular Mutagenesis
Volume 47, Issue 1, January 2006, Pages 6–17
Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effect

B.I. Ghanayem1, K.L. Witt1, G.E. Kissling1, R.R. Tice2, L. Recio2

1 National Institute of Environmental Health Sciences, National Institutes of Health
2 ILS, Inc.

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Volume 578, Issues 1–2, 15 October 2005, Pages 284–297
Proton-induced genetic damage in lacZ transgenic mice

P.Y. Chang, J. Bakke, J. Orduna, S. Lin, R. Doppalapudi

SRI International

Radiation Research
Volume 164, Issue 4, Part 2, October 2005, Pages 481-486
The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis

L. van der Weyden1, K.K. Tachibana2, M.A. Gonzalez2, D.J. Adams1, B.L. Ng1, R. Petty1, A.R. Venkitaraman2, M.J. Arends3, A. Bradley1

1 Wellcome Trust Sanger Institute
2 Hutchinson/MRC Research Centre
3 University of Cambridge, Addenbrooke's Hospital

Molecular and Cellular Biology
Volume 25, Issue 18, September 2005, Pages 8356-8367
Flow cytometric analysis of micronucleated reticulocytes: Time- and dose-dependent response of known mutagens in mice, using multiple blood sampling

M. De Boeck, B.J. van der Leede, F. Van Goethem, A. De Smedt, M. Steemans, A. Lampo, P. Vanparys

Johnson & Johnson Pharmaceutical Research & Development - a Division of Janssen Pharmaceutica N.V.

Environmental and Molecular Mutagenesis
Volume 46, Issue 1, July 2005, Pages 30–42
Micronucleated erythrocyte frequency in control and azidothymidine-treated Tk+/+, Tk+/- and Tk-/- mice

V.N. Dobrovolsky, L.J. McGarrity, L.S. VonTungeln, R.A. Mittelstaedt, S.M. Morris, F.A. Beland, R.H. Heflich

U.S. Food and Drug Administration/National Center for Toxicological Research

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Volume 570, Issue 2, 1 March 2005, Pages 227–235
Interlaboratory validation of a CD71-based flow cytometric method (MicroFlow®) for the scoring of micronucleated reticulocytes in mouse peripheral blood

D.K. Torous1, N.E. Hall1, A.H. Illi-Love2, M.S. Diehl2, K. Cederbrant3, K. Sandelin3, I. Pontén3, G. Bolcsfoldi3, L.R. Ferguson4, A. Pearson4, J.B. Majeska5, J.P. Tarca5, G.M. Hynes6, A.M. Lynch6, J.P. McNamee7, P.V. Bellier7, M. Parenteau7, D. Blakey7, J. Bayley7, B.J.M. van der Leede8, P. Vanparys8, P.R. Harbach9, S. Zhao9, A.L. Filipunas9, C.W. Johnson9, C.R. Tometsko1, S.D. Dertinger1

1 Litron Laboratories
2 Abbott Laboratories
3 AstraZeneca
4 University of Auckland
5 Boehringer Ingelheim Pharmaceuticals
6 GlaxoSmithKline
7 Health Canada
8 Johnson and Johnson Pharmaceutical Research and Development, a division of Janssen Pharmaceutica
9 Pharmacia Corporation

Environmental and Molecular Mutagenesis
Volume 45, Issue 1, 2005, Pages 44–55
Cytotoxic and genotoxic effect of the [166Dy]Dy/166Ho-EDTMP in vivo generator system in mice

M. Pedraza-López1, G. Ferro-Flores2, C. Arteaga de Murphy1, P. Morales-Ramírez2, J. Piedras-Ross1, E. Murphy-Stack3, O. Hernández-Oviedo4

1 Instituto Nacional de Ciencias Médicas y Nutrición
2 Instituto Nacional de Investigaciones Nucleares
3 Hospital Santaelena
4 Instituto Politécnico Nacional

Nuclear Medicine and Biology
Volume 31, Issue 8, November 2004, Pages 1079–1085
The influence of dietary flaxseed and other grains, fruits and vegetables on the frequency of spontaneous chromosomal damage in mice

G.A. Trentin1, J. Moody1, D.K. Torous2, L.U. Thompson3, J.A. Heddle1

1 York University
2 Litron Laboratories
3 University of Toronto

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Volume 551, Issues 1–2, 13 July 2004, Pages 213–222
Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice

R.A. Mittelstaedt1, N. Mei1, P.J. Webb1, J.G. Shaddock1, V.N. Dobrovolsky1, L.J. McGarrity1, S.M. Morris1, T. Chen1, F.A. Beland1, K.J. Greenlees2, R.H. Heflich1

1 U.S. Food and Drug Administration, National Center for Toxicological Research
2 Center for Veterinary Medicine, U.S. Food and Drug Administration

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 561, Issues 1–2, 11 July 2004, Pages 127–138
Gene expression profile in bone marrow and hematopoietic stem cells in mice exposed to inhaled benzene

B. Faiola, E.S. Fuller, V.A. Wong, L. Recio

CIIT Centers for Health Research

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Volume 549, Issues 1–2, 18 May 2004, Pages 195–212
Health effects of subchronic exposure to environmental levels of diesel exhaust

M.D. Reed1, A.P. Gigliotti1, J.D. McDonald1, J.C. Seagrave1, S.K. Seilkop2, J.L. Mauderly1.

1 Lovelace Respiratory Research Institute
2 SKS Consulting Services

Inhalation Toxicology
Volume 16, Issue 4, April 2004, Pages 177-193
Three-color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood

S.D. Dertinger1, K. Camphausen2, J.T. MacGregor3, M.E. Bishop3, D.K. Torous1, S. Avlasevich1, S. Cairns1, C.R. Tometsko1, C. Menard2, T. Muanza2, Y. Chen4, R.K. Miller5, K. Cederbrant6, K. Sandelin6, I. Pontén6, G. Bolcsfoldi6

1 Litron Laboratories
2 National Cancer Institute
3 FDA National Center for Toxicological Research
4 University of Rochester
5 University of Rochester Medical Center
6 AstraZeneca Research and Development

Environmental and Molecular Mutagenesis
Volume 44, Issue 5, 2004, Pages 427–435
Spontaneous and mitomycin C-induced micronuclei in peripheral blood reticulocytes from severely malnourished rats

R. Ortiz, H. Medina, L. Rodríguez, H. González-Márquez, E. Cortés

Universidad Autónoma Metropolitana-Iztapalapa

Environmental and Molecular Mutagenesis
Volume 43, Issue 3, 2004, Pages 179–185
Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity

A.K. Bauer1, B. Faiola1, D.J. Abernethy1, R. Marchan1, L.J. Pluta1, V.A. Wong1, F.J. Gonzalez2, B.E. Butterworth1, S.J. Borghoff1, J.I. Everitt1, L. Recio1

1 CIIT Centers for Health Research
2 National Cancer Institute

Toxicological Sciences
Volume 72, Issue 2, April 2003, Pages 201-209
Genetic susceptibility to benzene-induced toxicity: role of NADPH: quinone oxidoreductase-1

A.K. Bauer1, B. Faiola1, D.J. Abernethy1, R. Marchan1, L.J. Pluta1, V.A. Wong1, K. Roberts1, A.K. Jaiswal2, F.J. Gonzalez3, B.E. Butterworth1, S. Borghoff1, H. Parkinson1, J. Everitt1, L. Recio1

1 CIIT Centers for Health Research
2 Baylor College of Medicine
3 National Cancer Institute

Cancer Research
Volume 63, Issue 5, 01 March 2003, Pages 929-935
Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy

D.K. Torous, N.E. Hall, F.G. Murante, S.E. Gleason, C.R. Tometsko, SD. Dertinger

Litron Laboratories

Toxicological Sciences
Volume 74, Issue 2, 2003, Pages 309-314
The single laser flow cytometric micronucleus test: a time course study using colchicine and urethane in rat and mouse peripheral blood and acetaldehyde in rat peripheral blood

G.M. Hynes1, D.K. Torous2, C.R. Tometsko2, B. Burlinson1 and D.G. Gatehouse1

1 GlaxoWellcome
2 Litron Laboratories

Mutagenesis
Volume 17, Issue 1, January 2002, Pages 15-23
Induction and time-dependent accumulation of micronuclei in peripheral blood of transgenic p53+/– mice, Tg.AC (v-Ha-ras) and parental wild-type (C57BL/6 and FVB/N) mice exposed to benzene by inhalation

L.N. Healy1, L.J. Pluta1, R.A. James1, D.B. Janszen1, D. Torous2, J.E. French3, L. Recio1

1 CIIT
2 Litron Laboratories
3 National Institute of Environmental Health Sciences

Mutagenesis
Volume 16, Issue 2, March 2001, Pages 163-168
Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo

S.D. Dertinger, D.A. Nazarenko, A.E. Silverstone, T.A. Gasiewicz

University of Rochester School of Medicine

Carcinogenesis
Volume 22, Issue 1, January 2001, Pages 171-177
Flow cytometric enumeration of micronucleated reticulocytes: high transferability among 14 laboratories

D.K. Torous1, N.E. Hall1, S.D. Dertinger1, M.S. Diehl2, A.H. Illi-Love2, K. Cederbrant3, K. Sandelin3, G. Bolcsfoldi3, L.R. Ferguson4, A. Pearson4, J.B. Majeska5, J.P. Tarca5, D.R. Hewish6, L. Doughty6, M. Fenech6, J.L. Weaver7, D.D. Broud7, D.G. Gatehouse8, G.M. Hynes8, P. Kwanyuen8, J. McLean9, J.P. McNamee9, M. Parenteau9, V. Van Hoof10, P. Vanparys10, M. Lenarczyk11, J. Siennicka11, B. Litwinska11, M.G. Slowikowska11, P.R. Harbach12, C.W. Johnson12, S. Zhao12, C.S. Aaron12, A.M. Lynch13, I.C. Marshall13, B. Rodgers14, C.R. Tometsko1

1 Litron Laboratories
2 Abbott Laboratories
3 AstraZeneca
4 Auckland Cancer Society
5 Boehringer Ingelheim Pharmaceuticals
6 CSIRO (Commonwealth Scientific and Industrial Research Organization) Health Sciences and Nutrition, 7 Food and Drug Administration/CDER (Center for Drug Evaluation and Research)
8 GlaxoWellcome
9 Health Canada
10 Janssen Pharmaceutica
11 National Institute of Hygiene
12 Pharmacia & Upjohn
13 SmithKline Beecham
14 Texas Tech University

Environmental and Molecular Mutagenesis
Volume 38, Issue 1, 2001, Pages 59–68
Evaluation of the rodent micronucleus assay by a 28-day treatment protocol: Summary of the 13th Collaborative Study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Environmental Mutagen Society of Japan (JEMS)-Mammalian Mutagenicity Study Group (MMS)

S. Hamada1, S. Sutou2, T. Morita3, A. Wakata4, S. Asanami5, S. Hosoya6, S. Ozawa7, K. Kondo8, M. Nakajima9, H. Shimada10, K. Osawa11, Y. Kondo12, N. Asano13, S.I. Sato14, H. Tamura15, N. Yajima16, R. Marshall17, C. Moore18, D.H. Blakely19, L.M. Schechtman20, J.L. Weaver20, D.K. Torous21, R. Proudlock22, S. Ito23, C. Namiki1, M. Hayashi24

1 SSP Company, Ltd.
2 The National Institute of Bioscience and Human-Technology
3 Nippon Glaxo Ltd.
4 Yamanouchi Pharmaceutical Company, Ltd.
5 Otsuka Pharmaceutical Factory, Inc.
6 Safety Research Institute for Chemical Compounds Company, Ltd.
7 Kissei Pharmaceutical Company, Ltd.
8 Shionogi & Company, Ltd.
9 An-pyo Center
10 Daiichi Pharmaceutical Company
11 Taisho Pharmaceutical Company
12 Tanabe Seiyaku Company, Ltd.
13 Nitto Denko Corporation
14 Japan Tobacco Inc.
15 Nippon Shinyaku Company, Ltd.
16 Snow Brand Milk Products Company, Ltd.
17 Covance Laboratories Ltd.
18 ZENECA Pharmaceuticals
19 Health Canada
20 Food and Drug Administration
21 Litron Laboratories
22 Huntingdon Life Sciences
23 Nippon Experimental Medical Research Institute Company Ltd.
24 National Institute of Health Sciences

Environmental and Molecular Mutagenesis
Volume 37, Issue 2, 2001, Pages 93–177
Flow cytometry assay for counting micronucleated erythrocytes: development process

J.L. Weaver1, D. Torous2

1 Center for Drug Evaluation and Research, Food and Drug Administration
2 Litron Laboratories Inc.

Methods
Volume 21, Issue 3, July 2000, Pages 281-287
Impact of p53 status on heavy-ion radiation-induced micronuclei in circulating erythrocytes

P.Y. Chang1, D. Torous2, L. Lutze-Mann3, R. Winegar4

1 SRI International
2 Litron Laboratories
3 University of New South Wales
4 Midwest Research Institute

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 466, Issue 1, 3 March 2000, Pages 87–96
Enumeration of micronucleated reticulocytes in rat peripheral blood: a flow cytometric study

D.K. Torous1, SD. Dertinger2, N.E. Hall1, C.R. Tometsko1

1 Litron Laboratories
2 University of Rochester

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 465, Issues 1–2, 16 February 2000, Pages 91–99
Malaria-infected erythrocytes serve as biological standards to ensure reliable and consistent scoring of micronucleated erythrocytes by flow cytometry

S.D. Dertinger1,2, D.K. Torous2, N.E. Hall2, C.R. Tometsko2, T.A. Gasiewicz1

1 University of Rochester School of Medicine
2 Litron Laboratories

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 464, Issue 2, 24 January 2000, Pages 195–200
Influence of aromatic hydrocarbon receptor-mediated events on the genotoxicity of cigarette smoke condensate

S.D. Dertinger1, A.E. Silverstone2, T.A. Gasiewicz1

1 University of Rochester School of Medicine
2 State University of New York Upstate Medical University

Carcinogenesis
Volume 19, Issue 11, November 1998, Pages 2037-2042
An automated method for discriminating aneugen- vs. clastogen-induced micronuclei

D.K. Torous1, S.D. Dertinger2, N.E. Hall1, C.R. Tometsko1

Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 31, Issue 4, 1998, Pages 340–344
Flow cytometric analysis of micronucleated reticulocytes in mouse bone marrow

S.D. Dertinger, D.K. Torous, K.R. Tometsko

Litron Laboratories

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 390, Issue 3, 23 May 1997, Pages 257–262
Simple and reliable enumeration of micronucleated reticulocytes with a single-laser flow cytometer

S.D. Dertinger, D.K. Torous, K.R. Tometsko

Litron Laboratories

Mutation Research/Genetic Toxicology
Volume 371, Issues 3–4, 20 December 1996, Pages 283-292
Induction of micronuclei by low doses of azidothymidine (AZT)

S.D. Dertinger, D.K. Torous, K.R. Tometsko

Litron Laboratories

Mutation Research/Genetic Toxicology
Volume 368, Issues 3–4, 5 July 1996, Pages 301-307
Analysis of micronucleated cells by flow cytometry. 4. Kinetic analysis of cytogenetic damage in blood

A.M. Tometsko, S.D. Dertinger, D.K. Torous

Litron Laboratories

Mutation Research/Environmental Mutagenesis and Related Subjects
Volume 334, Issue 1, February 1995, Pages 9-18
Analysis of micronucleated cells by flow cytometry. 3. Advanced technology for detecting clastogenic activity

A.M. Tometsko, D.K. Torous, S.D. Dertinger

Litron Laboratories

Mutation Research/Environmental Mutagenesis and Related Subjects
Volume 292, Issue 2, October 1993, Pages 145-153
Analysis of micronucleated cells by flow cytometry. 2. Evaluating the accuracy of high-speed scoring

A.M. Tometsko, S.D. Dertinger, D.K. Torous

Litron Laboratories

Mutation Research/Environmental Mutagenesis and Related Subjects
Volume 292, Issue 2, October 1993, Pages 137-143
Analysis of micronucleated cells by flow cytometry. 1. Achieving high resolution with a malaria model

A.M. Tometsko, D.K. Torous, S.D. Dertinger

Litron Laboratories

Mutation Research/Environmental Mutagenesis and Related Subjects
Volume 292, Issue 2, October 1993, Pages 129-135