Publications using 
In Vitro MultiFlow Family of Kits

Benchmark Dose Analysis of DNA Damage Biomarker Responses Provides Compound Potency and Adverse Outcome Pathway Information for the Topoisomerase II Inhibitor Class of Compounds

R.P. Wheeldon1, D.T. Bernacki2, S.D. Dertinger2, S.M. Bryce2, J.C. Bemis2, G.E. Johnson1

1 Swansea University
2 Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 61, Issue 4, 01 April 2020, Pages 396-407 Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro

D.J. Smart, F.R. Helbling, M. Verardo, A. Huber, D. McHugh, P. Vanscheeuwijck

PMI R&D

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 849, 01 January 2020 Evidence for an Aneugenic Mechanism of Action for Micronucleus Induction by Black Cohosh Extract

D.T. Bernacki1, S.M. Bryce1, J.C. Bemis1, S.D. Dertinger1, K.L. Witt2, S.L. Smith-Roe2

1 Litron Laboratories
2 Division of the National Toxicology Program, NIEHS

Environmental and Molecular Mutagenesis
Volume 60, Issue 9, 01 December 2019, Pages 845-856 Aneugen Molecular Mechanism Assay: Proof-of-Concept With 27 Reference Chemicals

D.T. Bernacki, S.M. Bryce, J.C. Bemis, S.D. Dertinger

Litron Laboratories

Toxicological Sciences
Volume 170, Issue 2, 01 August 2019, Pages 382-393 Predictions of Genotoxic Potential, Mode of Action, Molecular Targets, and Potency via a Tiered MultiFlow® Assay Data Analysis Strategy

S.D. Dertinger1, A.R. Kraynak2, R.P. Wheeldon3, D.T. Bernacki1, S.M. Bryce1, N. Hall1, J.C. Bemis1, S.M. Galloway2, P.A. Escobar2, G.E. Johnson3

1 Litron Laboratories
2 Merck & Co., Inc.
3 Swansea University

Environmental and Molecular Mutagenesis
Volume 60, Issue 6, 01 July 2019, Pages 513-533 Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells

X. Guo1, J.E. Seo1, S.M. Bryce2, J.A. Tan1, Q. Wu1, S.L. Dial1, M.M. Moore1, N. Mei1

1 National Center for Toxicological Research
2 Litron Laboratories

Toxicological Sciences
Volume 163, Issue 1, 01 May 2018, Pages 214-225 Bioengineering a non-genotoxic vector for genetic modification of mesenchymal stem cells

X. Chen, A. Nomani, N. Patel, F.S. Nouri, A. Hatefi

Rutgers, The State University of New Jersey

Biomaterials
Volume 152, 01 January 2018, Pages 1-14 Interlaboratory Evaluation of a Multiplexed High Information Content In Vitro Genotoxicity Assay

S.M. Bryce1, D.T. Bernacki1, J.C. Bemis1, R.A. Spellman2, M.E. Engel2, M. Schuler2, E. Lorge3, P.T. Heikkinen4, U. Hemmann5, V. Thybaud6, S. Wilde7, N. Queisser7, A. Sutter7, A. Zeller8, M Guérard8, D. Kirkland9, S.D. Dertinger1

1 Litron Laboratories
2 Pfizer Worldwide Research and Development
3 Servier Group
4 Orion Pharma
5 Sanofi-Aventis Deutschland GmbH
6 Sanofi
7 Bayer AG
8 Roche Pharma Research and Early Development
9 Kirkland Consulting

Environmental and Molecular Mutagenesis
Volume 58, Issue 3, 01 April 2017, Pages 146-161 γH2AX and p53 responses in TK6 cells discriminate promutagens and nongenotoxicants in the presence of rat liver S9

D.T. Bernacki1, S.M. Bryce1, J.C. Bemis1, D. Kirkland2, S.D. Dertinger1

1 Litron Laboratories
2 Kirkland Consulting

Environmental and Molecular Mutagenesis
Volume 57, Issue 7, 01 August 2016, Pages 546-558 Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach

S.M. Bryce, D.T. Bernacki, J.C. Bemis, S.D. Dertinger

Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 57, Issue 3, 01 April 2016, Pages 171-189 Interpreting in vitro micronucleus positive results: simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents

S.M. Bryce1, J.C. Bemis1, J.A. Mereness1, R.A. Spellman2, J. Moss2, D. Dickinson2, M.J. Schuler2, S.D. Dertinger1

1 Litron Laboratories
2 Pfizer Worldwide Research and Development

Environmental and Molecular Mutagenesis
Volume 55, Issue 7, 01 August 2014, Pages 542-555