Publications using 
In Vitro MultiFlow Family of Kits

(High Content Assays)

Evidence for an Aneugenic Mechanism of Action for Micronucleus Induction by Black Cohosh Extract

Derek T. Bernacki1, Steven M. Bryce1, Jeffrey C. Bemis1, Stephen D. Dertinger1, Kristine L. Witt2, Stephanie L. Smith-Roe2

1 Litron Laboratories
2 Division of the National Toxicology Program, NIEHS

Environmental and Molecular Mutagenesis
Volume 60, Issue 9, December 2019, Pages 845-856
Aneugen Molecular Mechanism Assay: Proof-of-Concept With 27 Reference Chemicals

D.T. Bernacki, S.M. Bryce, J.C. Bemis, S.D. Dertinger

Litron Laboratories

Toxicological Sciences
Volume 170, Issue 2, 01 August 2019, Pages 382–393
Predictions of Genotoxic Potential, Mode of Action, Molecular Targets, and Potency via a Tiered MultiFlow® Assay Data Analysis Strategy

S.D. Dertinger1, A.R. Kraynak2, R.P. Wheeldon3, D.T. Bernacki1, S.M. Bryce1, N. Hall1, J.C. Bemis1, S.M. Galloway2, P.A. Escobar2, G.E. Johnson3

1 Litron Laboratories
2 Merck & Co., Inc.
3 Swansea University

Environmental and Molecular Mutagenesis
Volume 60, Issue 6, 01 July 2019, Pages 513–533
Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells
 

X. Guo1, J.E. Seo1, S.M. Bryce2, J.A. Tan1, Q. Wu1, S.L. Dial1, M.M. Moore1, N. Mei1

1 National Center for Toxicological Research, US Food and Drug Administration
2 Litron Laboratories

Toxicological Sciences
Volume 163, Issue 1, 1 May 2018, Pages 214–225
Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells

X. Guo1, J.E. Seo1, S.M. Bryce2, J.A. Tan1, Q. Wu1, S.L. Dial1, M.M. Moore1, N. Mei1

1 National Center for Toxicological Research
2 Litron Laboratories

Toxicological Sciences
Volume 163, Issue 1, 01 May 2018, Pages 214–225
Bioengineering a non-genotoxic vector for genetic modification of mesenchymal stem cells

X. Chen, A. Nomani, N. Patel, F.S. Nouri, A. Hatefi

Rutgers, The State University of New Jersey

Biomaterials
Volume 152, 01 January 2018, Pages 1–14
Interlaboratory Evaluation of a Multiplexed High Information Content In Vitro Genotoxicity Assay

S.M. Bryce1, D.T. Bernacki1, J.C. Bemis1, R.A. Spellman2, M.E. Engel2, M. Schuler2, E. Lorge3, P.T. Heikkinen4, U. Hemmann5, V. Thybaud6, S. Wilde7, N. Queisser7, A. Sutter7, A. Zeller8, M Guérard8, D. Kirkland9, S.D. Dertinger1

1 Litron Laboratories
2 Pfizer Worldwide Research and Development
3 Servier Group
4 Orion Pharma
5 Sanofi-Aventis Deutschland GmbH
6 Sanofi
7 Bayer AG
8 Roche Pharma Research and Early Development
9 Kirkland Consulting

Environmental and Molecular Mutagenesis
Volume 58, Issue 3, April 2017, Pages 146–161
γH2AX and p53 responses in TK6 cells discriminate promutagens and nongenotoxicants in the presence of rat liver S9

D.T. Bernacki1, S.M. Bryce1, J.C. Bemis1, D. Kirkland2, S.D. Dertinger1

1 Litron Laboratories
2 Kirkland Consulting

Environmental and Molecular Mutagenesis
Volume 57, Issue 7, August 2016, Pages 546–558
Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach

S.M. Bryce, D.T. Bernacki, J.C. Bemis, S.D. Dertinger

Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 57, Issue 3, April 2016, Pages 171–189
Interpreting in vitro micronucleus positive results: simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents

S.M. Bryce1, J.C. Bemis1, J.A. Mereness1, R.A. Spellman2, J. Moss2, D. Dickinson2, M.J. Schuler2, S.D. Dertinger1

1 Litron Laboratories
2 Pfizer Worldwide Research and Development

Environmental and Molecular Mutagenesis
Volume 55, Issue 7, August 2014, Pages 542–555