Publications using 
In Vitro MultiFlow Family of Kits

The use of benchmark dose uncertainty measurements for robust comparative potency analyses

R.P. Wheeldon1, S.D. Dertinger2, S.M. Bryce2, J.C. Bemis2, G.E. Johnson1

1 Swansea University
2 Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 62, Issue 3, March 2021, Pages 203-215
In vitro and in silico genetic toxicity screening of flavor compounds and other ingredients in tobacco products with emphasis on ENDS

P.-H. Hung1, M. Savidge1, M. De1, J. Kang1,2, S.M. Healy1, L.G. Valerio Jr.1

1 U.S. Food and Drug Administration
2 U.S. Public Health Service Commissioned Corps

Journal of Applied Toxicology
Volume 40, Issue 11, November 2020, Pages 1566-1587
3Rs-friendly approach to exogenous metabolic activation that supports high-throughput genetic toxicology testing

S. Tian, A. Cyr, K. Zeise, S.M. Bryce, N. Hall, J.C. Bemis, S.D. Dertinger

Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 61, Issue 4, April 2020, Pages 408-432
Benchmark Dose Analysis of DNA Damage Biomarker Responses Provides Compound Potency and Adverse Outcome Pathway Information for the Topoisomerase II Inhibitor Class of Compounds

R.P. Wheeldon1, D.T. Bernacki2, S.D. Dertinger2, S.M. Bryce2, J.C. Bemis2, G.E. Johnson1

1 Swansea University
2 Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 61, Issue 4, 01 April 2020, Pages 396-407
Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro

D.J. Smart, F.R. Helbling, M. Verardo, A. Huber, D. McHugh, P. Vanscheeuwijck

PMI R&D

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 849, 01 January 2020
Evidence for an Aneugenic Mechanism of Action for Micronucleus Induction by Black Cohosh Extract

D.T. Bernacki1, S.M. Bryce1, J.C. Bemis1, S.D. Dertinger1, K.L. Witt2, S.L. Smith-Roe2

1 Litron Laboratories
2 Division of the National Toxicology Program, NIEHS

Environmental and Molecular Mutagenesis
Volume 60, Issue 9, 01 December 2019, Pages 845-856
Aneugen Molecular Mechanism Assay: Proof-of-Concept With 27 Reference Chemicals

D.T. Bernacki, S.M. Bryce, J.C. Bemis, S.D. Dertinger

Litron Laboratories

Toxicological Sciences
Volume 170, Issue 2, 01 August 2019, Pages 382-393
Predictions of Genotoxic Potential, Mode of Action, Molecular Targets, and Potency via a Tiered MultiFlow® Assay Data Analysis Strategy

S.D. Dertinger1, A.R. Kraynak2, R.P. Wheeldon3, D.T. Bernacki1, S.M. Bryce1, N. Hall1, J.C. Bemis1, S.M. Galloway2, P.A. Escobar2, G.E. Johnson3

1 Litron Laboratories
2 Merck & Co., Inc.
3 Swansea University

Environmental and Molecular Mutagenesis
Volume 60, Issue 6, 01 July 2019, Pages 513-533
Baseline effects of non-flavored e-liquids in the in vitro micronucleus assay

D.J. Smart, F.R. Helbling, D. McHugh, and P. Vanscheeuwijck

Philip Morris Products S.A.

Toxicology Research and Application
Volume 3, January-December 2019, Pages 1-9
Black Cohosh Extracts and Powders Induce Micronuclei, a Biomarker of Genetic Damage, in Human Cells

S.L. Smith-Roe1, C.D. Swartz2, K.G. Shepard2, S.M. Bryce3, S.D. Dertinger3, S. Waidyanatha1, G.E. Kissling1, S.S. Auerbach1, and K.L. Witt1

1 National Institute of Environmental Health Sciences
2 Integrated Laboratory Systems, Inc.
3 Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 59, Issue 5, June 2018, Pages 416-426
Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells

X. Guo1, J.E. Seo1, S.M. Bryce2, J.A. Tan1, Q. Wu1, S.L. Dial1, M.M. Moore1, N. Mei1

1 National Center for Toxicological Research
2 Litron Laboratories

Toxicological Sciences
Volume 163, Issue 1, 01 May 2018, Pages 214-225
Bioengineering a non-genotoxic vector for genetic modification of mesenchymal stem cells

X. Chen, A. Nomani, N. Patel, F.S. Nouri, A. Hatefi

Rutgers, The State University of New Jersey

Biomaterials
Volume 152, 01 January 2018, Pages 1-14
Classification of In Vitro Genotoxicants Using a Novel Multiplexed Biomarker Assay Compared to the Flow Cytometric Micronucleus Test

S. Wilde, M. Dambowsky, C. Hempt, A. Sutter, and N. Queisser

Bayer AG

Environmental and Molecular Mutagenesis
Volume 58, Issue 9, December 2017, Pages 662-677
Interlaboratory Evaluation of a Multiplexed High Information Content In Vitro Genotoxicity Assay

S.M. Bryce1, D.T. Bernacki1, J.C. Bemis1, R.A. Spellman2, M.E. Engel2, M. Schuler2, E. Lorge3, P.T. Heikkinen4, U. Hemmann5, V. Thybaud6, S. Wilde7, N. Queisser7, A. Sutter7, A. Zeller8, M Guérard8, D. Kirkland9, S.D. Dertinger1

1 Litron Laboratories
2 Pfizer Worldwide Research and Development
3 Servier Group
4 Orion Pharma
5 Sanofi-Aventis Deutschland GmbH
6 Sanofi
7 Bayer AG
8 Roche Pharma Research and Early Development
9 Kirkland Consulting

Environmental and Molecular Mutagenesis
Volume 58, Issue 3, 01 April 2017, Pages 146-161
γH2AX and p53 responses in TK6 cells discriminate promutagens and nongenotoxicants in the presence of rat liver S9

D.T. Bernacki1, S.M. Bryce1, J.C. Bemis1, D. Kirkland2, S.D. Dertinger1

1 Litron Laboratories
2 Kirkland Consulting

Environmental and Molecular Mutagenesis
Volume 57, Issue 7, 01 August 2016, Pages 546-558
Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach

S.M. Bryce, D.T. Bernacki, J.C. Bemis, S.D. Dertinger

Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 57, Issue 3, 01 April 2016, Pages 171-189
Interpreting in vitro micronucleus positive results: simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents

S.M. Bryce1, J.C. Bemis1, J.A. Mereness1, R.A. Spellman2, J. Moss2, D. Dickinson2, M.J. Schuler2, S.D. Dertinger1

1 Litron Laboratories
2 Pfizer Worldwide Research and Development

Environmental and Molecular Mutagenesis
Volume 55, Issue 7, 01 August 2014, Pages 542-555