Publications using
In Vitro MicroFlow Kits

(Micronucleus Analysis)

Assessing the concentration of phthalate esters (PAEs) and bisphenol A (BPA) and the genotoxic potential of treated wastewater (final effluent) in Saudi Arabia

I. Al-Saleh, R. Elkhatib, T. Al-Rajoudi, G. Al-Qudaihi

 

King Faisal Specialist Hospital & Research Centre

Science of The Total Environment
Volume 578, 01 February 2017, Pages 440-451
Transformation products in the water cycle and the unsolved problem of their proactive assessment: A combined in vitro/in silico approach

J. Menz, A.P. Toolaram, T. Rastogi, C. Leder, O. Olsson, K. Kümmerer, M. Schneider
 

Leuphana University Lüneburg

Environment International
Volume 98, January 2017, Pages 171–180
Size- and coating-dependent cytotoxicity and genotoxicity of silver nanoparticles evaluated using in vitro standard assays

X. Guo1, Y. Li1, J. Yan1, T. Ingle1, M.Y. Jones1, N. Mei1, M.D. Boudreau1, C.K. Cunningham1, M. Abbas1,2, A.M. Paredes1, T. Zhou3, M.M. Moore1, P.C. Howard1, T. Chen1

1 National Center for Toxicological Research, U.S. Food and Drug Administration
2 The University of Lahore
3 Center for Veterinary Medicine, U.S. Food and Drug Administration

Nanotoxicology
Volume 10, Issue 9, November 2016, Pages 1373-1384
Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9

C.L. Yauk1, J.K. Buick1, A. Williams1, C.D. Swartz2, L. Recio2, H.H. Li3, A.J. Fornace3, E.M. Thomson1, J. Aubrecht4

1 Health Canada, Ottawa
2 Integrated Laboratory Systems Inc
3 Georgetown University Medical Center
4 Pfizer Inc

Environmental and Molecular Mutagenesis
Volume 57, Issue 4, May 2016, Pages 243–260
Initial hazard screening for genotoxicity of photo-transformation products of ciprofloxacin by applying a combination of experimental and in-silico testing

A.P. Toolaram1, T. Haddad1,2, C. Leder1, K. Kümmerer1

1 Leuphana University of Lüneburg
2 University of Aleppo

Environmental Pollution
Volume 211, April 2016, Pages 148–156
LC-MS- and 1H NMR-Based Metabolomic Analysis and in Vitro Toxicological Assessment of 43 Aristolochia Species

J. Michl1, G.C. Kite2, S. Wanke3, O. Zierau3, G. Vollmer3, C. Neinhuis3, M.S.J. Simmonds2, M. Heinrich1

1 UCL School of Pharmacy
2 Royal Botanic Gardens
3 Technische Universität Dresden

Journal of Natural Products
Volume 79, Issue 1, 22 January 2016, Pages 30-37
Best practices for application of attachment cells to in vitro micronucleus assessment by flow cytometry

J.C. Bemis1, S.M. Bryce1, M. Nern2, M. Raschke2, A. Sutter2

1 Litron Laboratories
2 Bayer HealthCare

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 795, 1 January 2016, Pages 51–59
Genetic and rat toxicity studies of cyclodextrin glucanotransferase

R.R. Maronpot1, C.A. Hobbs2, J. Davis2, C. Swartz2, M. Boyle2, M. Koyanagi3, S.M. Hayashi3

1 Maronpot Consulting LLC
2 Integrated Laboratory Systems, Inc.
3 San-Ei Gen F.F.I., Inc.

Toxicology Reports
Volume 3, 2016, Pages 381–392
Incorporation of metabolic activation potentiates cyclophosphamide-induced DNA damage response in isogenic DT40 mutant cells

K. Hashimoto1,2, S. Takeda3, J.A. Swenberg1, J. Nakamura1

1 University of North Carolina at Chapel Hill
2 Takeda Pharmaceutical Company Limited
3 Kyoto University

Mutagenesis
Volume 30, Issue 6, November 2015, Pages 821-828
Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells

J.K. Buick1, I. Moffat1, A. Williams1, C.D. Swartz2, L. Recio2, D.R. Hyduke3,4, H.H. Li4, A.J. Fornace4, J. Aubrecht5, C.L. Yauk1

1 Health Canada
2 Integrated Laboratory Systems Inc.
3 Utah State University
4 Georgetown University Medical Center
5 Pfizer Inc.

Environmental and Molecular Mutagenesis
Volume 56, Issue 6, July 2015, Pages 520–534
Silver nanoparticles: correlating nanoparticle size and cellular uptake with genotoxicity

K.S. Butler, D.J. Peeler, B.J. Casey, B.J. Dair, R.K. Elespuru

U.S. Food and Drug Administration, Center for Devices and Radiological Health

Mutagenesis
Volume 30, Issue 4, July 2015, Pages 577-591
New approaches to advance the use of genetic toxicology analyses for human health risk assessment

G.E. Johnson1, W. Slob1, S.H. Doak1, M.D. Fellows2, B.B. Gollapudi3, R.H. Heflich4, B.J. Rees1, L.G. Soeteman-Hernández5, J.R. Verma1, J.W. Wills1, G.J.S. Jenkins1, P.A. White6

1 Swansea University
2 AstraZeneca
3 Exponent
4 National Centre for Toxicological Research, U.S. Food and Drug Administration
5 National Institute for Public Health and the Environment (RIVM)
6 Health Canada

Toxicology Research
Volume 3, 01 May 2015, Pages 667-676
Histone markers identify the mode of action for compounds positive in the TK6 micronucleus assay

J.R. Cheung, D.A. Dickinson, J. Moss, M.J. Schuler, R.A. Spellman, P.L. Heard

Pfizer Worldwide Research and Development

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 777, 1 January 2015, Pages 7–16
Validation of a high throughput flow cytometric in vitro micronucleus assay including assessment of metabolic activation in TK6 cells

A.V. Thougaard, J. Christiansen, T. Mow, JJ. Hornberg

H. Lundbeck A/S

Environmental and Molecular Mutagenesis
Volume 55, Issue 9, December 2014, Pages 704–718
Co-assessment of cell cycle and micronucleus frequencies demonstrates the influence of serum on the in vitro genotoxic response to amorphous monodisperse silica nanoparticles of varying sizes

L. Gonzalez1, M. Lukamowicz-Rajska2, L.C.J. Thomassen3, C.E.A. Kirschhock3, L. Leyns1, D. Lison4, J.A. Martens3, A. Elhajouji2, M. Kirsch-Volders1

1 Vrije Universiteit Brussel
2 Novartis Institutes for Biomedical Research
3 Center for Surface Chemistry and Catalysis
4 Université catholique de Louvain

Nanotoxicology
Volume 8, Issue 8, December 2014, Pages 876-884
Interpreting in vitro micronucleus positive results: simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents

S.M. Bryce1, J.C. Bemis1, J.A. Mereness1, R.A. Spellman2, J. Moss2, D. Dickinson2, M.J. Schuler2, S.D. Dertinger1

1 Litron Laboratories
2 Pfizer Worldwide Research and Development

Environmental and Molecular Mutagenesis
Volume 55, Issue 7, August 2014, Pages 542–555
Dose-response modeling of etoposide-induced DNA damage response

Z. Li1, B. Sun1, R.A. Clewell1, Y. Adeleye2, M.E. Andersen1, Q. Zhang1

1 The Hamner Institutes for Health Sciences
2 Unilever

Toxicological Sciences
Volume 137, Issue 2, February 2014, Pages 371-384
miR-34a suppresses mutagenesis by inducing apoptosis in human lymphoblastoid TK6 cells

X. Chen, Y. Zhang, J. Yan, R. Sadiq, T. Chen

National Center for Toxicological Research, Food and Drug Administration

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 758, Issues 1–2, 12 December 2013, Pages 35–40
Nonlinear responses for chromosome and gene level effects induced by vinyl acetate monomer and its metabolite, acetaldehyde in TK6 cells

R. Budinsky1, B. Gollapudi1, R.J. Albertini2, R. Valentine3, M. Stavanja4, J. Teeguarden5, R. Fensterheim6, D. Rick1, T. Lardie1, L. McFadden1, A. Green7, L. Recio7

 

1 The Dow Chemical Company
2 The University of Vermont
3 DuPont Haskell Global Centers for Health and Environmental Sciences
4 Celanese International Corporation
5 Pacific Northwest National Laboratory
6 RegNet Environmental Services
7 ILS

Environmental and Molecular Mutagenesis
Volume 54, Issue 9, December 2013, Pages 755–768
Genetic stability of bone marrow-derived human mesenchymal stromal cells in the Quantum System

M. Jones1, M. Varella-Garcia2, M. Skokan2, S. Bryce3, J. Schowinsky2, R. Peters1, B. Vang1, M. Brecheisen1, T. Startz1, N. Frank1, B. Nankervis1

1 Terumo BCT
2 University of Colorado–Denver, Anschutz Medical Campus
3 Litron Laboratories

Cytotherapy
Volume 15, Issue 11, November 2013, Pages 1323–1339
Multi-platform genotoxicity analysis of silver nanoparticles in the model cell line CHO-K1

X. Jiang1,2, R. Foldbjerg2, T. Miclaus2, L. Wang1, R. Singh3, Y. Hayashi2, D. Sutherland2, C. Chen1, H. Autrup2, C. Beer2

1 Chinese Academy of Science
2 Aarhus University
3 University of Leicester

Toxicology Letters
Volume 222, Issue 1, 12 September 2013, Pages 55–63
Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin

B. Sun1, S.M. Ross1, O.J. Trask1, P.L. Carmichael2, M. Dent2, A. White2, M.E. Andersen1, R.A. Clewell1

1 The Hamner Institutes for Health Sciences
2 Unilever

Toxicology in Vitro
Volume 27, Issue 6, September 2013, Pages 1877–1887
In vitro micronucleus assay for the analysis of total particulate matter in cigarette smoke: comparison of flow cytometry and laser scanning cytometry with microscopy

J. Yao1,2, Q. Gao2, Q. Mi2, X. Li2, M. Miao2, P. Cheng3, Y. Luo1

1 Kunming University of Science & Technology
2 Yunnan Academy of Tobacco Science
3 The University of Queensland, National Research Centre for Environmental Toxicology

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 755, Issue 2, 15 August 2013, Pages 120–125
Nitroxide TEMPO: a genotoxic and oxidative stress inducer in cultured cells

X. Guo1, R.A. Mittelstaedt1, L. Guo1, J.G. Shaddock1, R.H. Heflich1, A.H. Bigger2, M.M. Moore1, N. Mei1

1 National Center for Toxicological Research, Food and Drug Administration
2 Bigger Consulting

Toxicology in Vitro
Volume 27, Issue 5, August 2013, Pages 1496–1502
Genotoxicity of 2-bromo-3'-chloropropiophenone

F. Meng1, J. Yan1, Y. Li1, P.P. Fu1, L.H. Fossom2, R.K. Sood2, D.J. Mans2, P.I Chu2, M.M. Moore1, T. Chen1

1 National Center for Toxicological Research, Food and Drug Administration
2 Center for Drug Evaluation and Research, Food and Drug Administration

Toxicology and Applied Pharmacology
Volume 270, Issue 2, 15 July 2013, Pages 158–163
Biomarkers of exposure and effect in human lymphoblastoid TK6 cells following [13C2]-acetaldehyde exposure

B.C. Moeller1, L. Recio2, A. Green2, W. Sun1, F.A. Wright1, W.M. Bodnar1, J.A. Swenberg1

1 University of North Carolina
2 ILS

Toxicological Sciences
Volume 133, Issue 1, May 2013, Pages 1-12
Flow cytometric 96-well microplate-based in vitro micronucleus assay with human TK6 cells: protocol optimization and transferability assessment

S.M. Bryce1, S.L. Avlasevich1, J.C. Bemis1, M. Tate2, R.M. Walmsley2, F. Saad3, K. Van Dijck3, M. De Boeck3, F. Van Goethem3, M. Lukamowicz-Rajska4, A. Elhajouji4, S.D. Dertinger1

1 Litron Laboratories
2 Gentronix Ltd. and University of Manchester
3 Janssen Research and Development, A Division of Janssen Pharmaceutical
4 Novartis Institutes for Biomedical Research

Environmental and Molecular Mutagenesis
Volume 54, Issue 3, April 2013, Pages 180–194
Nongenotoxic apoptosis inducers do not produce misleading positive results in the TK6 cell-based GADD45a-GFP genotoxicity assay

C.H. Topham1, N. Billinton2, R.M. Walmsley1,2

1 The University of Manchester
2 Gentronix Ltd.

Toxicological Sciences
Volume 128, Issue 1, July 2012, Pages 79-91
Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay

Y. Li1, D.H. Chen2, J. Yan1, Y. Chen1, R.A. Mittelstaedt1, Y. Zhang1, A.S. Biris3, R.H. Heflich1, T. Chen1

1 National Center for Toxicological Research, U.S. Food and Drug Administration
2 Little Rock Central High School
3 University of Arkansas at Little Rock

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 745, Issues 1–2, 14 June 2012, Pages 4–10
Dose-response assessment of naphthalene-induced genotoxicity and glutathione detoxication in human TK6 lymphoblasts

L. Recio1, K.G. Shepard1, L.G. Hernández2, G.L. Kedderis3

1 Integrated Laboratory Systems
2 National Institute for Public Health and the Environment (RIVM)
3 Consultant

Toxicological Sciences
Volume 126, Issue 2, April 2012, Pages 405-412
Genotoxicity assessment of water soluble fractions of biodiesel and its diesel blends using the Salmonella assay and the in vitro MicroFlow® kit (Litron) assay

D. Morais Leme1, T. Grummt2, D. Palma de Oliveira3, A. Sehr2, S. Renz2, S. Reinel2, E.R.A. Ferraz3, M.R. Rodrigues de Marchi1, M. Canto Machado1, G.J. Zocolo1, M.A. Marin-Morales1

1 Universidade Estadual Paulista (UNESP)
2 Federal Environment Agency
3 Universidade de São Paulo (USP)

Chemosphere
Volume 86, Issue 5, February 2012, Pages 512–520
An overview of biodiesel soil pollution: data based on cytotoxicity and genotoxicity assessments

D. Morais Leme1, T. Grummt2, R. Heinze2, A. Sehr2, S. Renz2, S. Reinel2, D. Palma de Oliveira3, E.R.A. Ferraz3, M.R. Rodrigues de Marchi1, M. Canto Machado1, G.J. Zocolo1, M.A. Marin-Morales1

1 Universidade Estadual Paulista (UNESP)
2 Federal Environment Agency
3 Universidade de São Paulo (USP)

Journal of Hazardous Materials
Volumes 199–200, 15 January 2012, Pages 343–349
Comparative analysis of micronuclei and DNA damage induced by Ochratoxin A in two mammalian cell lines

R. Ali1,2, R.A. Mittelstaedt2, J.G. Shaddock2, W. Ding2, J.A. Bhalli2, Q.M. Khan1, R.H. Heflich2

1 National Institute for Biotechnology and Genetic Engineering (NIBGE)
2 U.S. Food and Drug Administration, National Center for Toxicological Research

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 723, Issue 1, 14 July 2011, Pages 58–64
A flow cytometry based in vitro micronucleus assay in TK6 cells--validation using early stage pharmaceutical development compounds

M. Lukamowicz1, K. Woodward1, M. Kirsch-Volders2, W. Suter1, A. Elhajouji1

1 Novartis Institutes for Biomedical Research
2 Vrije Universiteit Brussel

Environmental and Molecular Mutagenesis
Volume 52, Issue 5, June 2011, Pages 363–372
In vitro micronucleus screening of pharmaceutical candidates by flow cytometry in Chinese hamster V79 cells

J. Nicolette1, M. Diehl1, P. Sonders1, S. Bryce2, E. Blomme1

1 Abbott Laboratories
2 Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 52, Issue 5, June 2011, Pages 355–362
Miniaturized flow cytometry-based CHO-K1 micronucleus assay discriminates aneugenic and clastogenic modes of action

S.M. Bryce, S.L. Avlasevich, J.C. Bemis, S.D. Dertinger

Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 52, Issue 4, May 2011, Pages 280–286
Flow cytometric analysis of micronuclei in mammalian cell cultures: past, present and future

S. Avlasevich1, S. Bryce1, M. De Boeck2, A. Elhajouji3, F. Van Goethem2, A. Lynch4, J. Nicolette5, J. Shi6, S. Dertinger1

1 Litron Laboratories
2 Johnson and Johnson Pharmaceutical R&D, Janssen Pharmaceutica N.V.
3 Novartis Institutes for Biomedical Research
4 GlaxoSmithKline R&D
5 Abbott Laboratories
6 BioReliance Corp.

Mutagenesis
Volume 26, Issue 1, January 2011, Pages 147-152
Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose-response relationships

S.M. Bryce, S.L. Avlasevich, J.C. Bemis, S. Phonethepswath, S.D. Dertinger

Litron Laboratories

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 703, Issue 2, 21 December 2010, Pages 191–199
Advantages of human hepatocyte-derived transformants expressing a series of human cytochrome p450 isoforms for genotoxicity examination

T. Hashizume1, S. Yoshitomi1, S. Asahi1, R. Uematsu1, S. Matsumura1, F. Chatani1, H. Oda2

1 Takeda Pharmaceutical Company Limited
2 Nagoya University Graduate School of Bioagricultural Sciences

Toxicological Sciences
Volume 116, Issue 2, August 2010, Pages 488-497
High content flow cytometric micronucleus scoring method is applicable to attachment cell lines

S.M. Bryce1, J. Shi2, J. Nicolette3, M. Diehl3, P. Sonders3, S. Avlasevich1, S. Raja1, J.C. Bemis1, S.D. Dertinger1

1 Litron Laboratories
2 BioReliance
3 Abbott Laboratories

Environmental and Molecular Mutagenesis
Volume 51, Issue 3, April 2010, Pages 260–266
Further evaluation of a flow cytometric in vitro micronucleus assay in CHO-K1 cells: a reliable platform that detects micronuclei and discriminates apoptotic bodies

J. Shi, R. Bezabhie, A. Szkudlinska

BioReliance Corporation

Mutagenesis
Volume 25, Issue 1, January 2010, Pages 33-40
Evaluation of the Litron In Vitro MicroFlow Kit for the flow cytometric enumeration of micronuclei (MN) in mammalian cells

J.E. Collins1, P.C. Ellis2, A.T. White1, A.E.G. Booth1, C.E. Moore3, M. Burman1, R.W. Rees1, A.M. Lynch1

1 GlaxoSmithKline R&D
2 Pfizer Ltd.
3 Unilever

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 654, Issue 1, 30 June 2008, Pages 76–81
Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay

S.M. Bryce1, S.L. Avlasevich1, J.C. Bemis1, M. Lukamowicz2, A. Elhajouji2, F. Van Goethem3, M. De Boeck3, D. Beerens3, H. Aerts3, J. Van Gompel3, J.E. Collins4, P.C. Ellis‑4, A.T. White4, A.M. Lynch4, S.D. Dertinger1

1 Litron Laboratories
2 Novartis Pharma AG
3 Johnson & Johnson Pharmaceutical Research and Development, Division of Janssen Pharmaceutica N.V.
4 GlaxoSmithKline

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 650, Issue 2, 29 February 2008, Pages 181–195
In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity

S.M. Bryce, J.C. Bemis, S.L. Avlasevich, S.D. Dertinger,

Litron Laboratories

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 630, Issues 1–2, 15 June 2007, Pages 78–91
In vitro micronucleus scoring by flow cytometry: differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability

S.L. Avlasevich, S.M. Bryce, S.E. Cairns, S.D. Dertinger

Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 47, Issue 1, January 2006, Pages 56–66