Litron Laboratories - In Vitro MicroFlow Kits

B.S. Maselli¹, V. Cunha², H. Lim³, C. Bergvall³, R. Westerholm³, K. Dreij², T. Watanabe⁴, A.A. Cardoso⁵, S.A. Pozza⁶, G.A. Umbuzeiro^1,6, F. Kummrow^1,7

1 University of São Paulo
2 Karolinska Institutet
3 Stockholm University
4 Kyoto Pharmaceutical University
5 São Paulo State University
6 State University of Campinas
7 Federal University of São Paulo

Environmental and Molecular Mutagenesis
Volume 61, Issue 5, 01 June 2020, Pages 560-573 Development and Application of TK6-derived Cells Expressing Human Cytochrome P450s for Genotoxicity Testing

X. Li¹, S. Chen¹, X. Guo¹, Q. Wu¹, J.E. Seo¹, L. Guo¹, M.G. Manjanatha¹, T. Zhou¹, K.L. Witt ², N. Mei¹

1 U.S. Food and Drug Administration
2 National Institute of Environmental Health Sciences

Toxicological Sciences
Volume 175, Issue 2, 01 June 2020, Pages 251-265 Flow Cytometric Micronucleus Assay and TGx-DDI Transcriptomic Biomarker Analysis of Ten Genotoxic and Non-Genotoxic Chemicals in Human HepaRG™ Cells

J.K. Buick¹, A. Williams¹, R. Gagné¹, C.D. Swartz², L. Recio², S.S. Ferguson³, C.L. Yauk¹

1 Health Canada
2 Integrated Laboratory Systems Inc.
3 National Institute of Environmental Health Sciences

Genes and Environment
Volume 42, Article 5, 04 February 2020 Cytotoxicity and genotoxicity of cadmium oxide nanoparticles evaluated using in vitro assays

E. Demir^1,5, T. Qin¹, Y. Li^1,6, Y. Zhang¹, X. Guo¹, T. Ingle¹, J. Yan¹, A.I. Orza^2,3, A.S. Biris⁴, S. Ghorai¹, T. Zhou¹, T. Chen¹

1 U.S. Food and Drug Administration
2 Emory University School of Medicine
3 CellaCure LLC
4 University of Arkansas at Little Rock
5 Antalya Bilim University
6 Eli Lilly and Company

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volumes 850-851, 01 February 2020 - 01 March 2020 Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro

D.J. Smart, F.R. Helbling, M. Verardo, A. Huber, D. McHugh, P. Vanscheeuwijck

PMI R&D

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 849, 01 January 2020 Mode‐of‐action analysis of the effects induced by nicotine in the in vitro micronucleus assay

D.J. Smart, F.R. Helbling, M. Verardo, D. McHugh, P. Vanscheeuwijck

PMI R&D

Environmental and Molecular Mutagenesis
Volume 60, Issue 9, 01 December 2019, Pages 778-791 Use of in vitro bioassays to facilitate read-across assessment of nitrogen substituted heterocycle analogues of polycyclic aromatic hydrocarbons

M. Coulet¹, H. Latado¹, M. Moser¹, H. Besselink², M. Tate³, F. Minetto¹, C.C. Fontannaz¹, P. Serrant¹, J. Mollergues¹, D. Piguet¹, B. Schilter¹, M. Marin-Kuan¹

1 Nestlé Research Center
2 BioDetection Systems B.V.
3 Gentronix Limited

Toxicology in Vitro
Volume 59, 01 September 2019, Pages 281-291 Innovative drinking water treatment techniques reduce the disinfection-induced oxidative stress and genotoxic activity

J. Lundqvist¹, A. Andersson², A. Johannisson¹, E. Lavonen^3,4, G. Mandava¹, H. Kylin^2,5, D. Bastviken², A. Oskarsson¹

1 Swedish University of Agricultural Sciences
2 Linköping University
3 Norrvatten
4 Stockholm Vatten och Avfall
5 North-West University

Water Research
Volume 155, 15 May 2019, Pages 182-192 In vitro and in vivo genotoxicity of oxygenated polycyclic aromatic hydrocarbons

S. McCarrick¹, V. Cunha¹, O. Zapletal^1,2,3, J. Vondráček³, K. Dreij¹

1 Karolinska Institutet
2 Masaryk University
3 Institute of Biophysics of the Czech Academy of Sciences

Environmental Pollution
Volume 246, 01 March 2019, Pages 678-687 Relative potency of fifteen pyrrolizidine alkaloids to induce DNA damage as measured by micronucleus induction in HepaRG human liver cells

A. Allemang, C. Mahony, C. Lester, S. Pfuhler

Proctor & Gamble

Food and Chemical Toxicology
Volume 121, 01 November 2018, Pages 72-81 Role of apurinic/apyrimidinic nucleases in the regulation of homologous recombination in myeloma: mechanisms and translational significance

S. Kumar^1,2, S. Talluri^1,2, J. Pal^1,2,3, X. Yuan^1,2, R. Lu^1,2, P. Nanjappa^1,2, M.K. Samur^1,4, N.C. Munshi^1,2,4, M.A. Shammas^1,2

1 Dana Farber Cancer Institute
2 Veterans Administration Boston Healthcare System
3 Pt J.N.M. Medical College
4 Harvard Medical School

Blood Cancer Journal
Volume 8, Issue 10, 01 October 2018, Article 92 Micronucleus induction and cell cycle alterations produced by deoxynivalenol and its acetylated derivatives in individual and combined exposure on HepG2 cells

A. Juan-García, M. Taroncher, G. Font, M.J. Ruiz

University of Valencia

Food and Chemical Toxicology
Volume 118, 01 August 2018, Pages 719-725 Genotoxicity evaluation of the naturally-derived food colorant, gardenia blue, and its precursor, genipin

C.A. Hobbs¹, M. Koyanagi², C. Swartz¹, J. Davis¹, R. Maronpot³, L. Recio¹, S.M. Hayashi²

1 Integrated Laboratory Systems
2 San-Ei Gen F.F.I.
3 Maronpot Consulting LLC

Food and Chemical Toxicology
Volume 118, 01 August 2018, Pages 695-708 Evaluation of genotoxicity and mutagenic effects of vector/DNA nanocomplexes in transfected mesenchymal stem cells by flow cytometry

A. Nomani¹, X. Chen¹, A. Hatefi^1,2

1 Rutgers, The State University of New Jersey
2 Rutgers Cancer Institute of New Jersey

Acta Biomaterialia
Volume 74, 01 July 2018, Pages 236-246 Quaternary (triphenyl-) phosphonium compounds: Environmental behavior and toxicity

S. Brand¹, M.P. Schlüsener¹, D. Albrecht¹, U. Kunkel¹, C. Strobel², T. Grummt², T.A. Ternes¹

1 Federal Institute of Hydrology
2 German Environment Agency

Water Research
Volume 136, 01 June 2018, Pages 207-219 RNA-sequencing reveals long-term effects of silver nanoparticles on human lung cells

A.R. Gliga¹, S. Di Bucchianico¹, J. Lindvall², B. Fadeel¹, H.L. Karlsson¹

1 Karolinska Institute
2 Stockholm University

Scientific Reports
Volume 8, 27 April 2018, Article 6668 Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential

C.A. Hobbs¹, M. Koyanagi², C. Swartz¹, J. Davis¹, S. Kasamoto³, R. Maronpot⁴, L. Recio¹, S.M. Hayashi²

1 Integrated Laboratory Systems
2 San-Ei Gen F.F.I.
3 Public Interest Incorporated Foundation Biosafety Research Center
4 Maronpot Consulting LLC

Food and Chemical Toxicology
Volume 113, 01 March 2018, Pages 218-227 Genotoxicity evaluation of multi-component mixtures of polyaromatic hydrocarbons (PAHs), arsenic, cadmium, and lead using flow cytometry based micronucleus test in HepG2 cells

S. Muthusamy, C. Peng, J.C. Ng

The University of Queensland

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 827, 01 March 2018, Pages 9-18 Adduction to arginine detoxifies aflatoxin B1 by eliminating genotoxicity and altering in vitro toxicokinetic profiles

B.R. Rushing, M.I. Selim

East Carolina University

Oncotarget
Volume 9, Issue 4, 12 Jan 2018, Pages 4559-4570 Integration of the TGx-28.65 genomic biomarker with the flow cytometry micronucleus test to assess the genotoxicity of disperse orange and 1,2,4-benzenetriol in human TK6 cells

J.K. Buick¹, A. Williams¹, B. Kuo¹, J.W. Wills¹, C.D. Swartz², L. Recio², H.H. Li³, A.J. Fornace Jr.³, J. Aubrecht⁴, C.L. Yauk¹

1 Health Canada
2 Integrated Laboratory Systems
3 Georgetown University Medical Center
4 Pfizer

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Volume 806, 01 December 2017, Pages 51-62 Assessing the concentration of phthalate esters (PAEs) and bisphenol A (BPA) and the genotoxic potential of treated wastewater (final effluent) in Saudi Arabia

I. Al-Saleh, R. Elkhatib, T. Al-Rajoudi, G. Al-Qudaihi

King Faisal Specialist Hospital & Research Centre

Science of The Total Environment
Volume 578, 01 February 2017, Pages 440-451 Transformation products in the water cycle and the unsolved problem of their proactive assessment: A combined in vitro/in silico approach

J. Menz, A.P. Toolaram, T. Rastogi, C. Leder, O. Olsson, K. Kümmerer, M. Schneider

Leuphana University of Lüneburg

Environment International
Volume 98, 01 January 2017, Pages 171-180 Differential genotoxicity mechanisms of silver nanoparticles and silver ions

Y. Li^1,2, T. Qin^1,3, T. Ingle¹, J. Yan¹, W. He^1,4, J.J. Yin¹, T. Chen¹

1 U.S. Food and Drug Administration
2 Covance Laboratories
3 Bio-Medical Pharmaceutical Manufacturing Corporation
4 Kuching University

Archives of Toxicology
Volume 91, Issue 1, 01 January 2017, Pages 509-519 Size- and coating-dependent cytotoxicity and genotoxicity of silver nanoparticles evaluated using in vitro standard assays

X. Guo¹, Y. Li¹, J. Yan¹, T. Ingle¹, M.Y. Jones¹, N. Mei¹, M.D. Boudreau¹, C.K. Cunningham¹, M. Abbas^1,2, A.M. Paredes¹, T. Zhou¹, M.M. Moore¹, P.C. Howard¹, T. Chen¹

1 U.S. Food and Drug Administration
2 The University of Lahore

Nanotoxicology
Volume 10, Issue 9, 01 November 2016, Pages 1373-1384 Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9

C.L. Yauk¹, J.K. Buick¹, A. Williams¹, C.D. Swartz², L. Recio², H.H. Li³, A.J. Fornace³, E.M. Thomson¹, J. Aubrecht⁴

1 Health Canada
2 Integrated Laboratory Systems
3 Georgetown University Medical Center
4 Pfizer

Environmental and Molecular Mutagenesis
Volume 57, Issue 4, 01 May 2016, Pages 243-260 Initial hazard screening for genotoxicity of photo-transformation products of ciprofloxacin by applying a combination of experimental and in-silico testing

A.P. Toolaram¹, T. Haddad^1,2, C. Leder¹, K. Kümmerer¹

1 Leuphana University of Lüneburg
2 University of Aleppo

Environmental Pollution
Volume 211, 01 April 2016, Pages 148-156 Genetic and rat toxicity studies of cyclodextrin glucanotransferase

R.R. Maronpot¹, C.A. Hobbs², J. Davis², C. Swartz², M. Boyle², M. Koyanagi³, S.M. Hayashi³

1 Maronpot Consulting LLC
2 Integrated Laboratory Systems
3 San-Ei Gen F.F.I.

Toxicology Reports
Volume 3, 07 March 2016, Pages 381-392 LC-MS- and ¹H NMR-Based Metabolomic Analysis and in Vitro Toxicological Assessment of 43 Aristolochia Species

J. Michl¹, G.C. Kite², S. Wanke³, O. Zierau³, G. Vollmer³, C. Neinhuis³, M.S.J. Simmonds², M. Heinrich¹

1 UCL School of Pharmacy
2 Royal Botanic Gardens
3 Technische Universität Dresden

Journal of Natural Products
Volume 79, Issue 1, 22 January 2016, Pages 30-37 Best practices for application of attachment cells to in vitro micronucleus assessment by flow cytometry

J.C. Bemis¹, S.M. Bryce¹, M. Nern², M. Raschke², A. Sutter²

1 Litron Laboratories
2 Bayer HealthCare

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 795, 01 January 2016, Pages 51-59 Incorporation of metabolic activation potentiates cyclophosphamide-induced DNA damage response in isogenic DT40 mutant cells

K. Hashimoto^1,2, S. Takeda³, J.A. Swenberg¹, J. Nakamura¹

1 University of North Carolina at Chapel Hill
2 Takeda Pharmaceutical Company Limited
3 Kyoto University

Mutagenesis
Volume 30, Issue 6, 01 November 2015, Pages 821-828 Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells

J.K. Buick¹, I. Moffat¹, A. Williams¹, C.D. Swartz², L. Recio², D.R. Hyduke^3,4, H.H. Li⁴, A.J. Fornace⁴, J. Aubrecht⁵, C.L. Yauk¹

1 Health Canada
2 Integrated Laboratory Systems
3 Utah State University
4 Georgetown University Medical Center
5 Pfizer

Environmental and Molecular Mutagenesis
Volume 56, Issue 6, 01 July 2015, Pages 520-534 Silver nanoparticles: correlating nanoparticle size and cellular uptake with genotoxicity

K.S. Butler, D.J. Peeler, B.J. Casey, B.J. Dair, R.K. Elespuru

U.S. Food and Drug Administration

Mutagenesis
Volume 30, Issue 4, 01 July 2015, Pages 577-591 New approaches to advance the use of genetic toxicology analyses for human health risk assessment

G.E. Johnson¹, W. Slob¹, S.H. Doak¹, M.D. Fellows², B.B. Gollapudi³, R.H. Heflich⁴, B.J. Rees¹, L.G. Soeteman-Hernández⁵, J.R. Verma¹, J.W. Wills¹, G.J.S. Jenkins¹, P.A. White⁶

1 Swansea University
2 AstraZeneca
3 Exponent
4 U.S. Food and Drug Administration
5 National Institute for Public Health and the Environment (RIVM)
6 Health Canada

Toxicology Research
Volume 4, Issue 3, 01 May 2015, Pages 667-676 Histone markers identify the mode of action for compounds positive in the TK6 micronucleus assay

J.R. Cheung, D.A. Dickinson, J. Moss, M.J. Schuler, R.A. Spellman, P.L. Heard

Pfizer Worldwide Research and Development

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 777, 01 January 2015, Pages 7-16 Validation of a high throughput flow cytometric in vitro micronucleus assay including assessment of metabolic activation in TK6 cells

A.V. Thougaard, J. Christiansen, T. Mow, J.J. Hornberg

H. Lundbeck A/S

Environmental and Molecular Mutagenesis
Volume 55, Issue 9, 01 December 2014, Pages 704-718 Co-assessment of cell cycle and micronucleus frequencies demonstrates the influence of serum on the in vitro genotoxic response to amorphous monodisperse silica nanoparticles of varying sizes

L. Gonzalez¹, M. Lukamowicz-Rajska², L.C.J. Thomassen³, C.E.A. Kirschhock³, L. Leyns¹, D. Lison⁴, J.A. Martens³, A. Elhajouji², M. Kirsch-Volders¹

1 Vrije Universiteit Brussel
2 Novartis Institutes for Biomedical Research
3 Center for Surface Chemistry and Catalysis
4 Université catholique de Louvain

Nanotoxicology
Volume 8, Issue 8, 01 December 2014, Pages 876-884 Interpreting in vitro micronucleus positive results: simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents

S.M. Bryce¹, J.C. Bemis¹, J.A. Mereness¹, R.A. Spellman², J. Moss², D. Dickinson², M.J. Schuler², S.D. Dertinger¹

1 Litron Laboratories
2 Pfizer Worldwide Research and Development

Environmental and Molecular Mutagenesis
Volume 55, Issue 7, 01 August 2014, Pages 542-555 Dose-response modeling of etoposide-induced DNA damage response

Z. Li¹, B. Sun¹, R.A. Clewell¹, Y. Adeleye², M.E. Andersen¹, Q. Zhang¹

1 The Hamner Institutes for Health Sciences
2 Unilever

Toxicological Sciences
Volume 137, Issue 2, 01 February 2014, Pages 371-384 miR-34a suppresses mutagenesis by inducing apoptosis in human lymphoblastoid TK6 cells

X. Chen, Y. Zhang, J. Yan, R. Sadiq, T. Chen

U.S. Food and Drug Administration

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 758, Issues 1-2, 12 December 2013, Pages 35-40 Nonlinear responses for chromosome and gene level effects induced by vinyl acetate monomer and its metabolite, acetaldehyde in TK6 cells

R. Budinsky¹, B. Gollapudi¹, R.J. Albertini², R. Valentine³, M. Stavanja⁴, J. Teeguarden⁵, R. Fensterheim⁶, D. Rick¹, T. Lardie¹, L. McFadden¹, A. Green⁷, L. Recio⁷

1 The Dow Chemical Company
2 The University of Vermont
3 DuPont Haskell Global Centers for Health and Environmental Sciences
4 Celanese International Corporation
5 Pacific Northwest National Laboratory
6 RegNet Environmental Services
7 Integrated Laboratory Systems

Environmental and Molecular Mutagenesis
Volume 54, Issue 9, 01 December 2013, Pages 755-768 Genetic stability of bone marrow-derived human mesenchymal stromal cells in the Quantum System

M. Jones¹, M. Varella-Garcia², M. Skokan², S. Bryce³, J. Schowinsky², R. Peters¹, B. Vang¹, M. Brecheisen¹, T. Startz¹, N. Frank¹, B. Nankervis¹

1 Terumo BCT
2 University of Colorado–Denver
3 Litron Laboratories

Cytotherapy
Volume 15, Issue 11, 01 November 2013, Pages 1323-1339 Multi-platform genotoxicity analysis of silver nanoparticles in the model cell line CHO-K1

X. Jiang^1,2, R. Foldbjerg², T. Miclaus², L. Wang¹, R. Singh³, Y. Hayashi², D. Sutherland², C. Chen¹, H. Autrup², C. Beer²

1 Chinese Academy of Science
2 Aarhus University
3 University of Leicester

Toxicology Letters
Volume 222, Issue 1, 12 September 2013, Pages 55-63 Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin

B. Sun¹, S.M. Ross¹, O.J. Trask¹, P.L. Carmichael², M. Dent², A. White², M.E. Andersen¹, R.A. Clewell¹

1 The Hamner Institutes for Health Sciences
2 Unilever

Toxicology in Vitro
Volume 27, Issue 6, 01 September 2013, Pages 1877-1887 In vitro micronucleus assay for the analysis of total particulate matter in cigarette smoke: comparison of flow cytometry and laser scanning cytometry with microscopy

J. Yao^1,2, Q. Gao², Q. Mi², X. Li², M. Miao², P. Cheng³, Y. Luo¹

1 Kunming University of Science & Technology
2 Yunnan Academy of Tobacco Science
3 The University of Queensland, National Research Centre for Environmental Toxicology

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 755, Issue 2, 15 August 2013, Pages 120-125 Nitroxide TEMPO: a genotoxic and oxidative stress inducer in cultured cells

X. Guo¹, R.A. Mittelstaedt¹, L. Guo¹, J.G. Shaddock¹, R.H. Heflich¹, A.H. Bigger², M.M. Moore¹, N. Mei¹

1 U.S. Food and Drug Administration
2 Bigger Consulting

Toxicology in Vitro
Volume 27, Issue 5, 01 August 2013, Pages 1496-1502 Genotoxicity of 2-bromo-3'-chloropropiophenone

F. Meng, J. Yan, Y. Li, P.P. Fu, L.H. Fossom, R.K. Sood, D.J. Mans, P.I. Chu, M.M. Moore, T. Chen

U.S. Food and Drug Administration

Toxicology and Applied Pharmacology
Volume 270, Issue 2, 15 July 2013, Pages 158-163 Biomarkers of exposure and effect in human lymphoblastoid TK6 cells following [¹³C2]-acetaldehyde exposure

B.C. Moeller¹, L. Recio², A. Green², W. Sun¹, F.A. Wright¹, W.M. Bodnar¹, J.A. Swenberg¹

1 University of North Carolina
2 Integrated Laboratory Systems

Toxicological Sciences
Volume 133, Issue 1, 01 May 2013, Pages 1-12 Flow cytometric 96-well microplate-based in vitro micronucleus assay with human TK6 cells: protocol optimization and transferability assessment

S.M. Bryce¹, S.L. Avlasevich¹, J.C. Bemis¹, M. Tate², R.M. Walmsley², F. Saad³, K. Van Dijck³, M. De Boeck³, F. Van Goethem³, M. Lukamowicz-Rajska⁴, A. Elhajouji⁴, S.D. Dertinger¹

1 Litron Laboratories
2 Gentronix Ltd. and University of Manchester
3 Janssen Research and Development
4 Novartis Institutes for Biomedical Research

Environmental and Molecular Mutagenesis
Volume 54, Issue 3, 01 April 2013, Pages 180-194 Nongenotoxic apoptosis inducers do not produce misleading positive results in the TK6 cell-based GADD45a-GFP genotoxicity assay

C.H. Topham¹, N. Billinton², R.M. Walmsley^1,2

1 The University of Manchester
2 Gentronix Ltd.

Toxicological Sciences
Volume 128, Issue 1, 01 July 2012, Pages 79-91 Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay

Y. Li¹, D.H. Chen², J. Yan¹, Y. Chen¹, R.A. Mittelstaedt¹, Y. Zhang¹, A.S. Biris³, R.H. Heflich¹, T. Chen¹

1 U.S. Food and Drug Administration
2 Little Rock Central High School
3 University of Arkansas at Little Rock

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 745, Issues 1-2, 14 June 2012, Pages 4-10 Dose-response assessment of naphthalene-induced genotoxicity and glutathione detoxication in human TK6 lymphoblasts

L. Recio¹, K.G. Shepard¹, L.G. Hernández², G.L. Kedderis³

1 Integrated Laboratory Systems
2 National Institute for Public Health and the Environment (RIVM)
3 Consultant

Toxicological Sciences
Volume 126, Issue 2, 01 April 2012, Pages 405-412 Genotoxicity assessment of water soluble fractions of biodiesel and its diesel blends using the Salmonella assay and the in vitro MicroFlow^® kit (Litron) assay

D.M. Leme¹, T. Grummt², D. Palma de Oliveira³, A. Sehr², S. Renz², S. Reinel², E.R.A. Ferraz³, M.R. Rodrigues de Marchi¹, M.C. Machado¹, G.J. Zocolo¹, M.A. Marin-Morales¹

1 Universidade Estadual Paulista
2 Federal Environment Agency
3 Universidade de São Paulo

Chemosphere
Volume 86, Issue 5, 01 February 2012, Pages 512-520 An overview of biodiesel soil pollution: data based on cytotoxicity and genotoxicity assessments

D.M. Leme¹, T. Grummt², R. Heinze², A. Sehr², S. Renz², S. Reinel², D. Palma de Oliveira³, E.R.A. Ferraz³, M.R. Rodrigues de Marchi¹, M.C. Machado¹, G.J. Zocolo¹, M.A. Marin-Morales¹

1 Universidade Estadual Paulista
2 Federal Environment Agency
3 Universidade de São Paulo

Journal of Hazardous Materials
Volumes 199-200, 15 January 2012, Pages 343-349 Comparative analysis of micronuclei and DNA damage induced by Ochratoxin A in two mammalian cell lines

R. Ali^1,2, R.A. Mittelstaedt², J.G. Shaddock², W. Ding², J.A. Bhalli², Q.M. Khan¹, R.H. Heflich²

1 National Institute for Biotechnology and Genetic Engineering
2 U.S. Food and Drug Administration

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 723, Issue 1, 14 July 2011, Pages 58-64 A flow cytometry based in vitro micronucleus assay in TK6 cells--validation using early stage pharmaceutical development compounds

M. Lukamowicz¹, K. Woodward¹, M. Kirsch-Volders², W. Suter¹, A. Elhajouji¹

1 Novartis Institutes for Biomedical Research
2 Vrije Universiteit Brussel

Environmental and Molecular Mutagenesis
Volume 52, Issue 5, 01 June 2011, Pages 363-372 In vitro micronucleus screening of pharmaceutical candidates by flow cytometry in Chinese hamster V79 cells

J. Nicolette¹, M. Diehl¹, P. Sonders¹, S. Bryce², E. Blomme¹

1 Abbott Laboratories
2 Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 52, Issue 5, 01 June 2011, Pages 355-362 Miniaturized flow cytometry-based CHO-K1 micronucleus assay discriminates aneugenic and clastogenic modes of action

S.M. Bryce, S.L. Avlasevich, J.C. Bemis, S.D. Dertinger

Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 52, Issue 4, 01 May 2011, Pages 280-286 Flow cytometric analysis of micronuclei in mammalian cell cultures: past, present and future

S. Avlasevich¹, S. Bryce¹, M. De Boeck², A. Elhajouji³, F. Van Goethem², A. Lynch⁴, J. Nicolette⁵, J. Shi⁶, S. Dertinger¹

1 Litron Laboratories
2 Johnson and Johnson
3 Novartis Institutes for Biomedical Research
4 GlaxoSmithKline
5 Abbott Laboratories
6 BioReliance

Mutagenesis
Volume 26, Issue 1, 01 January 2011, Pages 147-152 Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose-response relationships

S.M. Bryce, S.L. Avlasevich, J.C. Bemis, S. Phonethepswath, S.D. Dertinger

Litron Laboratories

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 703, Issue 2, 21 December 2010, Pages 191-199 Advantages of human hepatocyte-derived transformants expressing a series of human cytochrome p450 isoforms for genotoxicity examination

T. Hashizume¹, S. Yoshitomi¹, S. Asahi¹, R. Uematsu¹, S. Matsumura¹, F. Chatani¹, H. Oda²

1 Takeda Pharmaceutical Company
2 Nagoya University Graduate School of Bioagricultural Sciences

Toxicological Sciences
Volume 116, Issue 2, 01 August 2010, Pages 488-497 High content flow cytometric micronucleus scoring method is applicable to attachment cell lines

S.M. Bryce¹, J. Shi², J. Nicolette³, M. Diehl³, P. Sonders³, S. Avlasevich¹, S. Raja¹, J.C. Bemis¹, S.D. Dertinger¹

1 Litron Laboratories
2 BioReliance
3 Abbott Laboratories

Environmental and Molecular Mutagenesis
Volume 51, Issue 3, 01 April 2010, Pages 260-266 Further evaluation of a flow cytometric in vitro micronucleus assay in CHO-K1 cells: a reliable platform that detects micronuclei and discriminates apoptotic bodies

J. Shi, R. Bezabhie, A. Szkudlinska

BioReliance

Mutagenesis
Volume 25, Issue 1, 01 January 2010, Pages 33-40 Evaluation of the Litron In Vitro MicroFlow Kit for the flow cytometric enumeration of micronuclei (MN) in mammalian cells

J.E. Collins¹, P.C. Ellis², A.T. White¹, A.E.G. Booth¹, C.E. Moore³, M. Burman¹, R.W. Rees¹, A.M. Lynch¹

1 GlaxoSmithKline
2 Pfizer
3 Unilever

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 654, Issue 1, 30 June 2008, Pages 76-81 Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay

S.M. Bryce¹, S.L. Avlasevich¹, J.C. Bemis¹, M. Lukamowicz², A. Elhajouji², F. Van Goethem³, M. De Boeck³, D. Beerens³, H. Aerts³, J. Van Gompel³, J.E. Collins⁴, P.C. Ellis⁴, A.T. White⁴, A.M. Lynch⁴, S.D. Dertinger¹

1 Litron Laboratories
2 Novartis Pharma
3 Johnson & Johnson
4 GlaxoSmithKline

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 650, Issue 2, 29 February 2008, Pages 181-195 In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity

S.M. Bryce, J.C. Bemis, S.L. Avlasevich, S.D. Dertinger,

Litron Laboratories

Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Volume 630, Issues 1-2, 15 June 2007, Pages 78-91 In vitro micronucleus scoring by flow cytometry: differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability

S.L. Avlasevich, S.M. Bryce, S.E. Cairns, S.D. Dertinger

Litron Laboratories

Environmental and Molecular Mutagenesis
Volume 47, Issue 1, 01 January 2006, Pages 56-66

Publications using
In Vitro MicroFlow Kits

(Micronucleus Analysis)

Publications using In Vitro MicroFlow Kits

(Micronucleus Analysis)

Publications using
In Vitro MicroFlow Kits