Litron Scientist Receives Award

September 24, 2016

dertinger-copy.pngDr. Stephen Dertinger, Director of Research at Litron Laboratories, was the 2016 recipient of the prestigious Alexander Hollaender Award. Presented at the Environmental Mutagenesis and Genomics Society (EMGS) meeting in Kansas City, (USA), the Hollaender Award recognizes “outstanding contributions in the application of the principles and techniques of environmental mutagenesis and genomics to the protection of human health.” 
 
Based on Dertinger’s contributions to the detection of DNA damage, the award was given “(in) recognition of his impact on how genotoxicity is evaluated in regulatory and applied science through his development of automatic methods of measuring micronuclei and mutations. His research is vitally important for safety assessment by regulatory agencies.” 
 
For more than 20 years, Dertinger’s research team has made significant advances to the practice of genetic toxicology testing. Early in his career, Dertinger contributed significantly to Litron’s effort to automate the in vivo micronucleus test, an established marker of chromosomal damage and a required regulatory assay. Subsequently, he turned his attention to the automation of the in vitro micronucleus assay for work in cell cultures. More recently, Dertinger and his team have focused on the development of an improved, more affordable in vivo mutation assay. By developing the method on an endogenous (Pig-a) gene and making it compatible with commonly used laboratory models, routine in vivo mutation testing has now become a reality.
 
Today, under Dertinger’s direction, Litron scientists are continuing to advance genetic toxicology testing with the development of MultiFlow™ kits. This new method simultaneously measures several important biomarkers associated with DNA damage. It is proving to be valuable for both the early screening of new compounds and as a follow-up to in vitro positive results.
 
Throughout his career, Dr. Dertinger has been an active participant in several expert groups and continues to help shape international testing strategies, working with such organizations as IWGT, ECVAM, and the ILSI-HESI Genetic Toxicology Testing Committee.